摘要
目的 探讨抗菌光动力疗法(antimicrobial photodynamic therapy,aPDT)治疗口源性口臭的疗效.方法 为了解决"aPDT或aPDT联合刮舌器(tongue scraper,TS)治疗口源性口臭是否比单独用刮舌器更有效"的问题,应用oral halitosis或oral malodor或bad breath和PDT或photodynamic inactivation或photodynamic therapy或photo-dynamic antimicrobial chemotherapy对PubMed、Cochrane 图书馆从建库开始到 2024 年 2 月 29 日的所有文献进行了无语言限制的检索.排除标准包括:非人类实验、体外研究、重复报道的文献、数据不详者、不使用 OralChromaTM作为测量仪器的综述、病例报告或实验方案.结果 最后纳入了 8 项随机对照试验,提取数据并进行数据处理后显示:在口臭治疗后立即降低硫化氢浓度方面,aPDT或aPDT+TS比TS具有更好的效果.还有一项研究报告显示:aPDT治疗后细菌载量下降,而 TS 治疗后细菌载量增加,这表明 aPDT 对口腔微生物的效果强于 TS.结论 aPDT或aPDT+TS对口源性口臭有效,但还需要更多、更严谨的试验和更进一步的研究,来探索不同时间间隔下aPDT治疗口源性口臭的临床效果.
Abstract
Objective To explore the efficacy of antimicrobial photodynamic therapy(aPDT)for the treatment of oral halitosis.Methods To address the question of whether aPDT or aPDT combined with a tongue scraper(TS)was more effective than using a tongue scraper alone for the treatment of oral halitosis,an unrestricted language search was con-ducted on all literature in PubMed and Cochrane libraries from the beginning to February 29,2024,using oral halitosis,oral malodor,bad breath,PDT or photodynamic inactivation or photodynamic therapy.Exclusion criteria included:non-human experiments,in vitro studies,duplicated literature,those with unavailable data,and OralChromeTMwas not used as a measurement instrument for reviews,case reports,or experimental protocols.Results Eight randomized controlled trials were included.After data extraction and processing,it was found that aPDT or aPDT+TS had better effects than TS in reducing H2 S concentration immediately after halitosis treatment.Another research report showed that the bacterial load decreased after aPDT treatment,while the bacterial load increased after TS treatment,indicating that aPDT had a stronger effect on oral microbiota than TS.Conclusion aPDT or aPDT+TS is effective in treating oral halitosis,but more rigorous experiments and further research are needed to explore the clinical effects of aPDT on oral halitosis at dif-ferent time intervals.
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