Clinical efficacy and influencing factors of tigecycline in treatment of infectious diseases
Objective To investigate the clinical efficacy and influencing factors of tigecycline in the treatment of infec-tious diseases.Methods A total of 746 medical records of patients treated with tigecycline in Shandong Provincial Hos-pital Affiliated to Shandong First Medical University during January 2017 and December 2020 were retrospectively col-lected,and the clinical data of patients were analyzed to evaluate the clinical efficacy and factors.Results This study included 726 valid cases.Respiratory infection(65.43%)and complicated intra-abdominal infection(cIAI)(27.13%)were the main infections.The clinical effective rate was 65.70%,and the incidence of adverse reactions was 4.68%.Logistic regression analysis showed that the risk factors for the failure of tigecycline treatment were malignant solid tumor(OR=1.931,95%CI:1.161-3.214,P=0.011),respiratory system infection(OR=1.704,95%CI:1.096-2.649,P=0.018),septic shock(OR=2.784,95%CI:1.766-4.389,P<0.001),mechanical ventilation(OR=1.809,95%CI:1.143-2.862,P=0.011)and continuous renal replacement therapy(CRRT)(OR=1.886,95%CI:1.136-3.129,P=0.014),while the protective factors were admission to ICU(OR=0.518,95%CI:0.309-0.870,P=0.013)and long duration(OR=0.952,95%CI:0.919-0.985,P=0.005).Conclusion Tigecycline is mainly used for the treat-ment of severe and complex infections caused by multidrug-resistant bacteria.Patients with malignant solid tumor,respiratory system infection,septic shock,mechanical ventilation and CRRT have higher risk of tigecycline treatment failure,which should be paid attention to during the treatment.
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