Short-term efficacy and safety of anticoagulant therapy in elderly patients with corona virus disease 2019
Objective To analyse short-term efficacy and safety of anticoagulant therapy in elderly patients with corona virus disease 2019.Methods The study included corona virus disease 2019 patients aged≥80 years who were admit-ted to Qilu Hospital of Shandong University between December 2022 and August 2023.They were divided into anticoag-ulant and non-anticoagulant groups according to whether they received anticoagulant therapy.The bleeding events and clinical outcomes during hospitalisation were observed in the two groups.Results A total of 254 patients with an aver-age age of 85 years were divided into the anticoagulant group(n=183)and the non-anticoagulant group(n=71).Compared with the non-anticoagulant group,there were more severe(45.90%vs.30.99%,P<0.001)and critically ill(16.39%vs.4.22%,P<0.001)patients in the anticoagulant group.Binary Logistic analysis showed that anticoagulant therapy(OR=9.224,95%CI:3.435-24.769)and non-steroidal anti-inflammatory drugs(OR=3.619,95%CI:1.696-7.723)were independent risk factors for bleeding events during hospitalisation.There were 33 deaths,of which,32(96.97%)patients were classified as critically ill.After propensity score matching(PSM)to balance baseline character-istics,the incidence of bleeding events in the anticoagulant group was significantly higher than that in the non-anticoagu-lant group(40.85%vs.8.45%,P<0.001).There was no significant difference in in-hospital mortality between the two groups(4.22%vs.4.22%,P>0.999).Conclusion Anticoagulant therapy does not reduce mortality in elderly patients with corona virus disease 2019 but result in more bleeding events.
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