A rare case of lung adenocarcinoma complicated with bullous pemphigoid successfully treated with EGFR-TKI almonertinib
Objective To explore the relationship between lung adenocarcinoma with EGFR sensitizing mutation and bullous pemphigoid,as well as the benefit of almonertinib.Methods Clinical data from a case of lung adenocarcinoma complicated with bullous pemphigoid was collected.Pathological and molecular diagnosis was confirmed through his-topathological examination and next-generation sequencing genetic testing.Literature review was then conducted to sum-marize and analyze the disease's pathogenesis and treatment options.Results The diagnosis of metastatic lung adeno-carcinoma with bullous pemphigoid was established through imaging and histopathology examination.Next-generation sequencing revealed a sensitizing mutation of exon 19 deletion in the EGFR gene.The patient was treated with almoner-tinib with regular chest CT evaluations.The anti-tumor treatment efficacy was assessed to be partial response,and the skin lesions continued to improve with no significant adverse reactions.Conclusion Targeted therapies can be consid-ered in patients with EGFR-mutant metastatic lung adenocarcinoma complicated by bullous pemphigoid and almonertinib demonstrates good efficacy and safety.
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