慢性鼻窦炎(chronic rhinosinusitis,CRS)临床表现为长期鼻塞、流涕、嗅觉减退,严重影响患者的生活质量.CRS发病具有高度异质性,伴有鼻息肉的"表型"为慢性鼻窦炎伴鼻息肉(chronic rhinosinusitis with nasal polyps,CRSwNP).针对传统治疗药物疗效有限和CRSwNP患者术后复发的问题,已开展多种靶向内在型标志物的生物制品临床试验.近年来,我国治疗 CRSwNP 的药物临床研究快速发展,国内企业自主研发品种不断涌现,为CRSwNP患者尤其是重度难治性CRSwNP患者带来了新的选择.通过探讨国内治疗CRSwNP药物临床研究现状和发展趋势,为我国CRSwNP治疗药物的研发提供信息参考.
Current status of drug clinical research for the treatment of chronic rhinosinusitis with nasal polyps in China
The clinical manifestations of chronic rhinosinusitis(CRS)are chronic nasal congestion,runny nose,and loss of sense of smell,which seriously affect the patients'quality of life.The pathogenesis of CRS is highly heterogene-ous,and the phenotype associated with nasal polyps is chronic rhinosinusitis with nasal polyps(CRSwNP).Clinical trials of various biological agents targeting intrinsic biomarkers have been conducted to address the limited efficacy of traditional treatment drugs and postoperative recurrence in patients with CRSwNP.In recent years,clinical research for the treatment of CRSwNP in China has flourished,and self-developed varieties of domestic enterprises continue to emerge,bringing new choices for CRSwNP patients,especially those with severe and refractory CRSwNP.By summari-zing the current status and development trends of clinical research for the treatment of CRSwNP in China,this study aims to provide information and reference for the research and development of drugs for treating CRSwNP.
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