Pharmaceutical characteristics and clinical utility of dipeptidyl peptidase-4 inhibitors
Diabetes mellitus is a global public health problem,which leads to enormous human suffering.The preva-lence of type 2 diabetes mellitus(T2DM)remains rising in China.Meanwhile,the awareness and control rate of diabe-tes have increased,but they are still at a low level.Dipeptidyl peptidase-4(DPP-4)inhibitors are novel oral antihyper-glycemic agents.The unique mechanism of DPP-4 inhibitors satisfy different clinical demands.However,the molecular structure,clinical application and safety information of available DPP-4 inhibitors are different.We focus specially on the different clinical pharmaceutical characters,efficacy,safety and application on special population of DPP-4 inhibi-tors,which aims to provide the best drugs for individual patients.
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