二肽基肽酶-4抑制剂的药学特点及临床应用
Pharmaceutical characteristics and clinical utility of dipeptidyl peptidase-4 inhibitors
林晓倩 1封茂燕 1牟正1
作者信息
- 1. 山东大学齐鲁医院(青岛)药学部,山东 青岛 266035
- 折叠
摘要
糖尿病是当今威胁人类健康的常见疾病之一,导致巨大的社会经济负担.我国2 型糖尿病患病率仍在上升,糖尿病的知晓率和控制率有所增加,但仍处于低水平.二肽基肽酶-4(dipeptidyl peptidase-4,DPP-4)抑制剂是新型上市的降糖药物,独特的作用机制满足了临床治疗对降糖药物的不同需求.然而,不同DPP-4 抑制剂的药学特征、临床应用及安全性信息等方面存在差异,且在其他疾病领域的应用已逐步展开研究.本研究围绕我国已上市的DPP-4抑制剂的药学特征、临床应用、安全性信息、特殊情况用药及新型DPP-4抑制剂的研发进行讨论,协助临床合理选用DPP-4抑制剂.
Abstract
Diabetes mellitus is a global public health problem,which leads to enormous human suffering.The preva-lence of type 2 diabetes mellitus(T2DM)remains rising in China.Meanwhile,the awareness and control rate of diabe-tes have increased,but they are still at a low level.Dipeptidyl peptidase-4(DPP-4)inhibitors are novel oral antihyper-glycemic agents.The unique mechanism of DPP-4 inhibitors satisfy different clinical demands.However,the molecular structure,clinical application and safety information of available DPP-4 inhibitors are different.We focus specially on the different clinical pharmaceutical characters,efficacy,safety and application on special population of DPP-4 inhibi-tors,which aims to provide the best drugs for individual patients.
关键词
糖尿病/二肽基肽酶-4抑制剂/药学特点/临床应用/安全性Key words
Diabetes mellitus/Dipeptidyl peptidase-4 inhibitors/Pharmaceutical characteristics/Clinical application/Drug safety引用本文复制引用
出版年
2024
NETL
NSTL
万方数据