Association of 25(OH)D,IGF-I,anxiety and depression symptoms with non-suicidal self-injury in outpatient adolescents with psychiatric disorders
Objective To investigate the effects of 25-hydroxyvitamin D[25(OH)D],insulin-like growth factor I(IGF-I),and anxiety and depression symptoms on non-suicidal self-injury(NSSI)in outpatient adolescents with psy-chiatric disorders.Methods A total of 234 outpatient adolescents with psychiatric disorders were selected for observa-tion.They were divided into two groups based on the presence of NSSI:a non-NSSI group(86 cases)and an NSSI group(148 cases).The patients were assessed using the Hamilton Depression Rating Scale(HAMD)and the Hamilton Anxiety Rating Scale(HAMA).Serum levels of 25(OH)D and IGF-I were measured.Differences in variables between the two groups were compared.Binary Logistic regression was used to determine the risk factors for NSSI,and receiver operating characteristic(ROC)curve analysis was conducted to estimate the optimal cut-off values.Results The HAMA and HAMD scores in the NSSI group were significantly higher than those in the non-NSSI group(P<0.001),and the 25(OH)D levels were significantly lower in the NSSI group(P=0.001).Regression analysis revealed that the severity of depression symptoms(OR=1.186,95%CI=1.089-1.292,P<0.001)and 25(OH)D levels(OR=0.921,95%CI=0.857-0.990,P=0.026)were the influencing factors for NSSI in outpatient adolescents with psychiatric disor-ders.ROC analysis indicated that 25(OH)D level≤13.06 ng/mL and HAMD score≥18.50 were the best cut-off val-ues for the diagnosis of NSSI.Conclusion The levels of 25(OH)D and the severity of depression symptoms are the influencing factors for NSSI in outpatient adolescents with psychiatric disorders.Combined testing of these factors dem-onstrates good diagnostic predictive value.
NETL
NSTL
万方数据
