摘要
气道炎症性疾病主要包括变应性鼻炎、慢性鼻窦炎、哮喘、慢性阻塞性肺病等,其特征是气道炎症和气道高反应性.在过去的几年里,代谢组学已成为研究气道炎症性疾病的一个重要工具.随着分析技术的不断进步和新方法的开发,代谢组学的灵敏度、准确度和通量将得到进一步提高,从而更加深入了解变应性鼻炎、哮喘、慢性阻塞性肺病等疾病的代谢变化.本文概述代谢组学在各种气道炎症性疾病方面的研究进展,通过对血液、痰液、尿液、粪便、呼出气冷凝液等分析,揭示多种与炎症反应、氧化应激等相关的代谢通路和产物,以期为气道炎症性疾病的精准医疗提供新方向,为理解疾病的分子机制、发现潜在的生物标志物、评估治疗效果以及开发新的治疗方法提供全新视角.
Abstract
Airway inflammatory diseases,including allergic rhinitis,chronic sinusitis,asthma,and chronic obstructive pulmonary disease(COPD),are characterized by airway inflammation and airway hyperresponsiveness.Recently,metabolomics has emerged as a key tool for studying airway inflammatory diseases.Advances in analytical techniques are enhancing its sensitivity,accuracy,and throughput,offering deeper insights into metabolic changes in conditions like allergic rhinitis,asthma,and COPD.This review outlines advancements in metabolomics research on airway inflammatory diseases,and identifys metabolic pathways and products linked to inflammation and oxidative stress through analyses of blood,sputum,urine feces,and exhaled air condensate.It aims to guide precision medicine,en-hance understanding of disease mechanisms,identify biomarkers,evaluate treatment efficacy,and develop new therapies.
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