Design and Exploration of the Synthetic Routes of Novel M-Diamide Compounds Containing Sulfur
Broflanilide which possessed high efficiency,low toxicity,and no cross resistance with traditional insecticides acting on GABA receptor was globally registered in 2020.The research on its structural modification and biological activity was extremely rare,so possessed broad research market.Based on the literature research results and the classic organic reactions,two synthesis routes were designed according to the principle of pesticide designing.The easy derivatization sulfur elements with diverse biological activities were introduced into Broflanilide.The corresponding target compounds were successfully prepared by the second synthesis route for two-line with methyl 2-fluoro-3-nitrobenzoate as the starting material,and the structures were confirmed by combining the physical and chemical data characterization,which provide a solid foundation for the synthesis of m-diamide compounds containing sulfur and their biological activities.
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