老药新用在乳腺癌治疗中的研究进展
Research progress in drug repurposing in the treatment of breast cancer
谭辰 1徐张润 2薛阳 3陈佳钰 4姚力郡5
作者信息
- 1. 上海交通大学医学院附属第六人民医院骨科,上海 200030
- 2. 上海交通大学医学院分子生物学实验室,上海 200025
- 3. 上海交通大学医学院附属第六人民医院检验科,上海 200030
- 4. 上海交通大学医学院附属第九人民医院心内科,上海 200011
- 5. 上海交通大学医学院附属第六人民医院内分泌代谢科,上海 200030
- 折叠
摘要
乳腺癌作为全球女性发病率最高的癌症,给世界女性健康造成了巨大负担.现有的治疗方法成本高昂且伴有耐药的风险.老药新用作为一种效益高且省时的药物研究策略,越来越受到研究者们的关注.许多已经用于临床或正在进行临床试验的药物,可用于新的临床适应证.基于对药物作用机制和乳腺癌病理生理过程的深入了解,研究者们可以更好地聚焦具备抗乳腺癌潜力的药物并将其转化到临床实践中.该文综述了目前与乳腺癌治疗相关的老药新用的研究,归纳总结这些药物的作用机制,探讨老药新用策略面临的挑战.
Abstract
Breast cancer has become one of the most prevalent cancers among women worldwide,posing a significant burden on their health.Current standard therapies are often expensive and associated with the risk of drug resistance.Drug repurposing has gained increasing attention as a cost-effective and time-saving strategy in pharmaceutical research.Many drugs already in clinical use or undergoing clinical trials can be repurposed for the treatment of new clinical indications.Based on a comprehensive understanding of the mechanisms of action of these drugs and the pathophysiological processes of breast cancer,researchers can better identify drugs with potential anti-breast cancer properties and translate them into clinical practice.This paper provides a review of the current research on repurposing existing drugs for breast cancer treatment,summarizes the mechanisms of action of these drugs,and discusses the challenges associated with the strategy of drug repurposing.
关键词
老药新用/乳腺癌/化学治疗/抗肿瘤Key words
drug repurposing/breast cancer/chemotherapy/anti-tumor引用本文复制引用
出版年
2024
NETL
NSTL
万方数据