Objective To detect the changes of oral Pg before,during and after radiotherapy in patients with esophageal cancer,and to explore the role of radiotherapy on oral Pg clearance.Methods Thirty pa-tients with pathologically proven esophageal squamous cell carcinoma were selected for the formulation of a modulated intensity modulated radiotherapy plan using the Elekta-precise planning system.The prescribed dose was 50～50.4 Gy/25～28 times.Oral swabs(6 per person,180 in total)were collected once a week be-fore,during and after radiotherapy.Quantitative detection of Pg was performed by qPCR.Statistical data were analyzed by rank sum test.Results The results of initial oral Pg detection in 30 patients with esophageal cancer were as follows:60％(18/30)were negative and 40％(12/30)were positive.Among the 12 positive patients,83.33％(10/12)were negative and 16.67％(2/12)were still positive after radiotherapy(for the two patients,the amount of Pg was significantly reduced compared with that before radiotherapy(P＜0.05).Conclusion Patients with esophageal cancer,oral Pg can be simultaneously eliminated or reduced dur-ing radiotherapy on the cancer.
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