Objective To analyze the value of 18F-FDG PET/CT combined with serum miR-22 expres-sion in preoperative TNM staging of esophageal cancer(EC).Methods The clinical data of 164 patients with EC who underwent surgical treatment in our hospital from February 2018 to February 2023 were retro-spectively analyzed.All patients underwent preoperative 18F-FDG PET/CT examination and serum miR-22 expression detection,and the postoperative pathological examination was confirmed to be EC and the TNM staging was clarified.18F-FDG PET/CT metabolic parameters[maximum standardized uptake value(SUV-max),metabolic tumor volume(MTV)and total lesion glycolysis(TLG)]and serum miR-22 expression in each stage were compared.Using pathological results as the"gold standard",the value of 18F-FDG PET/CT metabolic parameters combined with serum miR-22 expression for preoperative TNM staging of EC was analyzed.Results The SUVmax of T3 and T4 stage EC patients was higher than that of T1 stage EC patients(P＜0.05),while the SUVmax of T4 stage EC patients was higher than that of T2 stage EC patients(P＜0.05).The TLG of T3 and T4 stage EC patients was higher than that of T1 and T2 stage EC patients(P＜0.05),while the TLG of T4 stageEC patients was higher than that of T3 stage EC pa-tients(P＜0.05).The SUVmax of N1-3 stage EC patients was greater than that of N0 stage EC patients(P＜0.05).There were statistically significant differences in the expression of serum miR-22 among patients with different T,N and M stages EC(P＜0.05),and the expression of miR-22 in serum of patients with T1,T2,T3 and T4 stages of EC decreased sequentially(P＜0.05).The accuracy of combining 18F-FDG PET/CT metabolic parameters with serum miR-22 expression in evaluating T1,T2,T3,N and M staging of EC were higher than those of single evaluation(P＜0.05),while the accuracy of evaluating T4 staging of EC was higher than that of 18F-FDG PET/CT met-abolic parameters evaluated separately(P＜0.05).Conclusion There are differences in 18F-FDG PET/CT metabolic parameters and serum miR-22 expression in EC patients with different TNM stages,and the e-valuation value of 18F-FDG PET/CT metabolic parameters combined with serum miR-22 expression for pre-operative TNM staging of EC is higher than that of the two alone.
国家科技期刊平台
NSTL
万方数据
