目的 检索、评价并总结肿瘤患者免疫治疗相关胃肠道反应的预防及管理最佳证据,为临床提供参考.方法 在国内外相关网站及数据库(UpToDate计算机决策支持系统、BMJ最佳临床实践、澳大利亚JBI网站、美国国立临床诊疗指南数据库、国际指南协作网、苏格兰院际指南网、世界肿瘤学网络、美国国家癌症综合网络、医脉通指南网,英国国家卫生与临床优化研究所、美国医疗保健与研究质量局、加拿大安大略注册护士协会、多国癌症支持治疗协会、美国临床肿瘤学会、癌症免疫治疗协会等网站,以及Cochrane Library、Embase、CHINAL、Web of Science、OVID、PubMed、SinoMed、知网、万方、维普数据库等数据库)中,系统检索关于肿瘤患者免疫治疗胃肠道反应预防及管理的临床指南、最佳临床实践信息册、推荐实践、证据总结、专家共识、系统评价及相关原始研究.检索时限为建库2022年9月1日.由2名研究者独立进行文献质量评价和资料提取,在结合临床专业人员判断的基础上进行证据总结.结果 共纳入17篇文献,包括6篇指南、1篇证据总结、3篇专家共识、3篇系统评价、1篇随机对照试验及3篇队列研究,围绕肿瘤患者免疫治疗相关胃肠道反应的预防及管理,汇总了胃肠道评估、危险因素、基线筛查、诊断检查、药物治疗、胃肠道护理、健康教育7个方面的23条最佳证据.结论 该研究总结了肿瘤患者免疫治疗胃肠道反应预防及管理的最佳证据,为医护人员临床实践提供循证依据.
Summary of Evidence for Prevention and Management of Immunotherapy-associated Gastrointestinal Reactions in Cancer Patients
Objective To retrieve,evaluate and summarize the best evidence for the prevention and management of immunotherapy-associated gastrointestinal reactions in cancer patients,providing reference for clinical practice.Methods Clinical guidelines,best clinical practice manuals,recommended practices,summaries of evidence,expert consensuses,systematic reviews and original studies on the prevention and management of immunotherapy-associated gastrointestinal reactions in cancer patients were retrieved from the following professional websites and databases from their establishment to September 1,2022:UpToDate Clinical Decision Support System,BMJ Best Practice,Australia Joanna Briggs Institute Evidence-Based Healthcare Center,US National Guideline Clearinghouse,Guidelines International Network,Scottish Intercollegiate Guidelines Network,World Oncology Network,US National Comprehensive Cancer Network,Medlive,UK National Institute for Health and Care Excellence,US Agency for Healthcare Research and Quality,Canada Registered Nurses'Association of Ontario,Multinational Association of Supportive Care in Cancer,American Society of Clinical Oncology,Society for Immunotherapy of Cancer,Cochrane Library,Embase,CHINAL,Web of Science,OVID,PubMed,SinoMed,CNKI,Wanfang Data and VIP.Two investigators evaluated the quality of the articles,extracted relevant data,and summarized evidence based on the judgment of clinical professionals.Results A total of 17 articles were included,including 6 guidelines,1 summary of evidence,3 expert consensuses,3 systematic reviews,1 randomized controlled trial and 3 cohort studies.Focused on the prevention and management of immunotherapy-associated gastrointestinal reactions in cancer patients,23 pieces of best evidence were summarized,covering the following 7 aspects:gastrointestinal assessment,risk factors,baseline screening,diagnostic examinations,drug therapy,gastrointestinal nursing and health education.Conclusion The best evidence for the prevention and management of immunotherapy-associated gastrointestinal reactions in cancer patients summarized based on an evidence-based approach can provide healthcare providers with theoretical support for clinical practice.
CancerImmunotherapyGastrointestinal adverse reactionnursingPreventionSummary of evi-denceEvidence-based nursing
国家科技期刊平台
NSTL
万方数据
