The present paper,reconstructing the history,in which Alexios I,one of the Byzantine emperors,granted Chrysobull to Venice and advance greatly the city state's maritime development and Mediterranean trade,contends that,from the long run,Chrysobull exerted multiple negative influences on Venice on the grounds that other coastal city states such as Genoa and Pisa obtained privileges to trade through such e-dict and there were inevitable competitions and even violent conflicts leading to the decline of Byzantine Empire finally.