抗精神病药物与肝损伤
Antipsychotic Drugs and Liver Injury
吕钦谕 1易正辉1
作者信息
- 1. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- 折叠
摘要
2015年10月中华医学会肝病学分会药物性肝病学组起草并推出了中国首部《药物性肝损伤诊治指南》,对药源性肝损伤(DILl)临床诊治提出了建议.作为精神科医生,临床也发现无论是典型还是新型抗精神病药物均会不同程度引起肝脏损伤,因此需要快速准确的判断肝损伤发生的原因,损伤的类型和程度,确立解决方案.本文复习了相关文献,包括抗精神病药物所致药源性肝损伤常见的发病机制和临床表现、实验室检查、诊断标准和分型、临床管理策略,最后对抗精神病药物所致肝损伤进行了总结和展望.
Abstract
In October 2015,the drug-induced liver diseases group of the Chinese Society of Hepatology drafted and published the first Diagnosis and Treatment Guidelines on Drug-induced Liver Injury in China,giving suggestions on the diagnosis and treatment of drug-induced liver injury (DILl).As a psychiatrist,I have found that in clinical practice both typical and new antipsychotic drugs can induce liver injury to varying degrees.Therefore,it is necessary to quickly and accurately determine the cause of liver injury and the type and severity of injury and establish a solution.This article reviewed relevant literature including the common pathogenesis and clinical manifestations of drug-induced liver injury caused by antipsychotic drugs,laboratory tests,diagnostic criteria and classification,and clinical management strategies.This paper also includes a summary and a perspective on liver injury caused by antipsychotic drugs.
关键词
抗精神病药物/药源性肝损伤Key words
antipsychotic drugs/drug-induced liver injury引用本文复制引用
基金项目
National Natural Science Foundation of China(81671326)
National Basic Research Program of China(2016YFC0906402)
Shanghai Mental Health Center Program(2017-YJ-01)
Shanghai Mental Health Center Program(2015-YJGJ-03)
Fundamental Research Funds for the Central Universities(16JXRZ06)
Shanghai Science and Technology Commission Foundation(17411970000)
出版年
2018
NETL
NSTL
维普
万方数据