大剂量“笑气”吸食致神经精神症状1例病例报告
Neuropsychiatric Symptoms Induced by Large Doses of Nitrous Oxide Inhalation: A Case Report
陈天真 1钟娜 1江海峰 1赵敏 1陈志康 1孙海明1
作者信息
- 1. Shanghai Mental Health Center, Shanghai Jiao Tong University, Shanghai, China
- 折叠
摘要
一氧化二氮,俗称“笑气”,已经成为全球第七大滥用药物. “笑气”吸食后影响维生素B12代谢,造成神经损伤,产生显著的精神神经症状.对于这类患者,及时的识别和治疗有助于改善预后.本文报告1例19岁的青年男性,在近半年时间内大剂量吸食“笑气”,出现幻听、被害妄想、关系妄想和情绪不稳.同时存在肢体无力,全身“手套-袜套”样痛觉过敏等神经症状.予大剂量维生素B12补充为主的治疗后,患者精神症状改善,神经损害好转,但下肢远端未完全恢复.治疗上,应遵循成瘾综合干预措施,除了及时修复神经损害外,还应增强患者治疗动机,针对复吸诱发因素加强干预,这对患者长期预后及回归社会非常有益.
Abstract
Nitrous Oxide,which is also called laughing gas,now ranks as the 7th most popular drug in the world.Nitrous oxide mainly disturbs B12 metabolism and damages nerves,followed by apparent neuropsychiatric symptoms.It's beneficial to the prognosis of patients if we identify and treat their symptoms early.This case report describes a 19-year-old male who presented with auditory hallucination,persecutory delusions and unstable emotions after abuse of nitrous oxide over the course of half a year.Moreover,neurological signs such as weakness and hyperesthesia also appeared.After supplementation of vitamin B12,the neuropsychiatric symptoms improved,while the lower extremities achieved partial recovery.Therapeutically,we should pay attention to nerve repair,motivation enhancement and reinforce interventions that prevent relapse.
关键词
一氧化二氮/维生素B12/神经损害/精神障碍Key words
nitrous oxide/vitamin B12/neurologic impairment/mental disorders引用本文复制引用
基金项目
National Natural Science Foundation Joint Fund Key Project(U1502228)
Shanghai Municipal Science and Technology Committee of Shanghai Outstanding Academic Leaders Plan(17XD1403300)
Joint Project of Shanghai health and Family Planning Commission(2014ZYJB0002)
Shanghai Mental Health Center Grant(2014-QH-01)
National Natural Science Foundation of China(81601164)
A pioneer Grant of Shanghai Mental Health Center(2016-FX-03)
出版年
2018
NETL
NSTL
维普
万方数据