甲基苯丙胺所致精神病性障碍与精神分裂症患者工作记忆缺陷的比较研究
A Comparison Study of Working Memory Deficits between Patients with Methamphetamine-Associated Psychosis and Patients with Schizophrenia
甘鸿 1宋振华 1许珮玮 1苏杭 1潘盈盈 1赵敏 1刘登堂1
作者信息
- 1. First-episode Schizophrenia and Early Psychosis Program, Division of Psychotic Disorders, Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China;Shanghai Key Laboratory of Psychotic Disorders, Shanghai Mental Health Center, School of Medicine, Shanghai Jiao Tong University, Shanghai, China
- 折叠
摘要
背景:甲基苯丙胺所致精神病性障碍(methamphetamine-associated psychosis,MAP)患者和精神分裂症患者均存在明显的工作记忆等认知功能缺陷,并且均影响患者的功能预后.目的:探讨MAP患者和精神分裂症患者工作记忆缺陷,尤其中央执行系统功能的差异,以及工作记忆缺损与临床特征的相关性.方法:共入组了28例男性MAP患者及28例男性精神分裂症患者.应用基于语言材料编制的n-back任务评估被试的工作记忆.应用阳性与阴性症状量表(PANSS)的阳性量表及临床总体印象量表(CGI)评估患者的精神症状及其严重程度.结果:对n-back数据进行重复测验方差分析,结果发现组间变量(组别)及组内变量(n)的主效应均显著,组间变量与组内变量的交互作用亦显著.经Z转换后,MAP患者及精神分裂症患者的工作记忆成绩分别为0.91 (0.77)和-0.91 (2.11),组间差异有统计学意义(F=19.253,p＜0.001).无论MAP患者或精神分裂症患者,其工作记忆缺陷与临床特征均缺乏相关性.结论:MAP患者对激活信息的管理、更新及执行控制能力优于精神分裂症患者.
Abstract
Background:Both patients with methamphetamine-associated psychosis (MAP) and patients with schizophrenia suffer from obvious cognitive deficits in working memory,and this affects the functional prognosis of patients.Aim:This study is to investigate the difference of working memory deficits between patients with MAP and patients with schizophrenia,espedally the difference of central executive system function,and the relevance of working memory deficits and clinical characteristics.Methods:Twenty-eight male patients with MAP and twenty-eight patients with schizophrenia were recruited.The working memory of subjects was evaluated with the n-back task edited and adapted from English language materials.The positive syndrome scale of PANSS and CGI were employed to assess psychotic symptoms and the severity of patientS.Results:According to the results of repeated measure variance analysis,it was found that both the between-group variable (group) and within-group variable (n) had significant main effects,and the interaction between the between-group variable and the within-group variable was also significant.After Z-transformation,mean (sd) working memory scores of patients with MAP and schizophrenia were 0.91 (0.77) and-0.91 (2.11) respectively,and the difference between these two groups were statistically significant (F=19.253,p＜0.001).The relevance between working memory deficits and clinical characteristics was low in both the patients with MAP and patients with schizophrenia.Conclusion:Patients with MAP were better at regulating,updating,executing and controlling active information than patients with schizophrenia.
关键词
甲基苯丙胺所致精神病性障碍/精神分裂症/工作记忆/n-back任务Key words
methamphetamine-associated psychosis/schizophrenia/working memory/n-back task引用本文复制引用
基金项目
International Collaborative Foundation of Shanghai Mental Health Center(2015-YJGJ-02)
Shanghai Municipal Health and Family Planning Commission(2014ZYJB0002)
National Natural Science Foundation of China(81771436)
National Natural Science Foundation of China(81371479)
Early Psychosis Program of Shanghai Mental Health Center(2013-YJTSZK-05)
Shanghai Key Laboratory of Psychotic Disorders(13dz2260500)
出版年
2018
NETL
NSTL
万方数据