重复经颅磁刺激对甲基苯丙胺诱导的大鼠条件性位置偏爱复吸行为的作用
The Effect of Repetitive Transcranial Magnetic Stimulation on the Reinstatement of Methamphetamine-Induced Conditioned Place Preference in Rats
武学庆 1居云悦 1焦东亮 2赵敏1
作者信息
- 1. Shanghai Mental Health Center, Collaborative Innovation Center for Brain Science, Shanghai Jiao Tong University School of Medicine, Shanghai, China
- 2. Department of Psychiatry, Bengbu Medical College, Bengbu, China
- 折叠
摘要
背景:甲基苯丙胺(Methamphetamine,METH)滥用已成为全球性的公共卫生问题,这类新型毒品不仅能够导致患者成瘾,还会造成认知功能损伤,目前尚无有效的治疗方法.重复经颅磁刺激(Repetitive transcranial magnetic stimulation,rTMS)是一种无痛、无创的绿色物理治疗方法,目前可用于临床治疗抑郁、焦虑、精神分裂、帕金森等神经精神疾病,并获得较好的疗效;但其对甲基苯丙胺成瘾的疗效与机制尚不明确,有待进一步研究.目的:探索rTMS对甲基苯丙胺成瘾复吸行为的作用.方法:本研究应用甲基苯丙胺诱导的条件性位置偏爱模型(Conditioned Place Preference,CPP),结合rTMS技术,在条件性位置偏爱行为消退后,分别对大鼠进行为期1天(实验一)和3天(实验二)的高频rTMS (10Hz)刺激,并于刺激结束后24小时进行复吸测试,探索急慢性rTMS对甲基苯丙胺诱导的大鼠CPP复吸行为的影响.结果:急性rTMS(刺激1天)对大鼠CPP的复吸行为具有一定的抑制作用,但与伪刺激组相比没有统计学意义(t=1.48,p=0.431);而慢性rTMS(刺激3天)对大鼠CPP的复吸行为有明显的抑制作用,与假刺激组相比,结果具有统计学意义(t=3.33,p=0.004).结论:rTMS慢性刺激能够抑制甲基苯丙胺诱导的大鼠CPP的复吸行为.
Abstract
Background:The abuse of methamphetamine (METH) has become a public health problem worldwide.This type of new drug can not only lead to addiction but can also cause cognitive impairment.Currently,there is no effective treatment.Repetitive transcranial magnetic stimulation (rTMS) is a painless and non-invasive green physiotherapy which can be used in the clinical treatment of neuropsychiatric disorders such as depression,anxiety,schizophrenia,and Parkinson's disease.However,whether it can be used to treat methamphetamine addiction is unclear.Objective:To explore the effect of rTMS on the relapse behavior of methamphetamine addiction.Methods:METH-induced rats conditioned place preference (CPP) model and rTMS technique were used in this study.Rats were given high frequency(10Hz) rTMS treatment for one day (experiment 1) or three days (experiment 2) after the extinction of CPP behavior.The reinstatement test was performed 24 hours after rTMS treatment and the effects of acute and chronic rTMS on the reinstatement of METH-induced CPP in rats were explored.Results:Acute rTMS treatment (1 day) had a trend of an inhibitory effect on the relapse behavior of METH-induced CPP,but it was not statistically significant compared with the sham stimulation group (t=1.48,p=0.431).However,chronic rTMS treatment (3 days) had a significant inhibitory effect on the reinstatement of METH-induced CPP compared with the sham stimulation group (t=-3.33,p=0.004).Conclusion:Chronic rTMS treatment inhibited the relapse behavior of METH-induced CPP in rats.
关键词
甲基苯丙胺/重复经颅磁刺激/条件性位置偏爱/复吸Key words
methamphetamine/repetitive transcranial magnetic stimulation/conditioned place preference/reinstatement引用本文复制引用
基金项目
National Key R&D Program of China,PI(2017YFC1310400)
National Natural Science Foundation of China(U1502228)
National Natural Science Foundation of China(81771436)
Shanghai Municipal Health and Family Planning Commission(2014ZYJB0002)
Program of Shanghai Academic Research Leader(17XD1403300)
Shanghai Key Laboratory of Psychotic Disorders(13DZ2260500)
key subject of Shanghai Municipal Health and Family Planning Commission(?)Psychiatry)(2017ZZ02021)
出版年
2018
NETL
NSTL
万方数据