PURPOSE:To investigate the effect of endoscopy-aided non-incisional periodontal regeneration technique(NIT)in the treatment of alveolar bone angular resorption.METHODS:Thirteen patients with severe periodontitis(13 dis-eased teeth)were selected.All patients had alveolar bone angular resorption on adjacent surface.The patients received NIT treatment 6 weeks after periodontal primary therapy.The visualization of subgingival environment was acquired by the periodontal endoscopy.Following the removal of the subgingival plaque,calculus and intra-bony granulation tissue,bone grafting materials were placed into the intra-bony defects with the assistance of a delicate gingival protector.No flap was elevated and no sutures were applied.Probing depth(PD),gingival recession(GR),clinical attachment level(CAL),as well as radiographic parameters were evaluated at baseline and 2 years after treatment.SPSS 22.0 software package was used for data analysis.RESULTS:At 2-years follow-up,an average CAL gain of(3.65±2.10)mm(P<0.001),PD reduction of(4.42±1.66)mm(P<0.001),and minimal increase in GR of(0.38±0.87)mm(P=0.25)were observed.Alveolar bone was sig-nificantly improved at 2-years follow-up on radiographs(P<0.001).CONCLUSIONS:For angular resorption site of alve-olar bone,NIT treatment can obtain good periodontal regeneration results without flap inversion.