小肠黏膜下层可吸收生物膜在牙槽骨缺损修复中的应用效果评价
Application of small intestinal submucosa absorbable biofilm in the repair of alveolar bone defects
张民珍 1邝惠芳 1杨黎艳 1罗文1
作者信息
- 1. 海南医学院第一附属医院 口腔科,海南 海口 570102
- 折叠
摘要
目的:探讨小肠黏膜下层(small intestinal submucosa,SIS)可吸收生物膜在牙槽骨缺损修复的临床疗效.方法:选择2020年1月-2022年1月接受引导骨再生术(guided bone regeneration,GBR)的 102例牙槽骨缺损患者,采用计算机随机数字生成器分为Bio-Gide组(51例,采用Bio-Gide可吸收生物膜)和SIS组(51例,采用SIS可吸收生物膜).比较2组围术期相关指标、血钙、血磷、生物相容性、牙周附着丧失(periodontal attachment loss,PAL)长度、牙髓敏感度、牙松动度、牙槽骨骨量及不良事件.采用SPSS 24.0软件包对数据进行统计学分析.结果:2组手术时间、术中出血量、术后第1天疼痛视觉模拟量表(VAS)评分、术后第5天VAS评分,术前、术后1 d、术后12 d血钙、血磷水平,术前、术后3个月、术后6个月、术后12个月PAL长度,术后3、6、12个月牙髓敏感度及牙松动度1级、2级百分率,术后12个月骨宽度增加量、骨高度增加量,不良事件发生率相比,差异均无统计学意义(P＞0.05).与Bio-Gide组相比,SIS组创口愈合时间、生物膜吸收时间显著缩短(P＜0.05),术后12 d排异反应发生率显著降低(P＜0.05).结论:SIS可吸收生物膜、Bio-Gide可吸收生物膜在牙槽骨缺损修复GBR中的效果及安全性相当,但前者生物相容性更佳,后者可提供更长时间的屏障功能.
Abstract
PURPOSE:To study the clinical efficacy of small intestinal submucosa(SIS)absorbable biological membrane in alveolar bone defect repair.METHODS:A total of 102 patients with alveolar bone defect who received guided bone regeneration(GBR)in our hospital from January 2020 to January 2022 were selected and divided into Bio-Gide group(51 cases using Bio-Gide absorbable biofilm)and SIS group(51 cases using SIS absorbable biofilm)by computer random number generator.The perioperative related indicators,blood calcium,blood phosphorus,biocompatibility,periodontal at-tachment loss(PAL)length,pulp sensitivity,tooth mobility,alveolar bone volume and adverse events of the two groups were compared.Statistical analysis was performed with SPSS 24.0 software package.RESULTS:There was no significant difference in operation time,intraoperative blood loss,visual analogue scale(VAS)score of pain on the first day after op-eration,VAS score on the fifth day after operation,wound healing time,blood calcium and phosphorus levels before oper-ation,1 d and 12 d after operation,PAL length before operation,3 months,6 months and 12 months after operation,pulp sensitivity and tooth looseness grade 1 and 2 percentage at 3,6 and 12 months after operation,bone width increase,bone height increase at 12 months after operation and adverse event rate between the two groups(P＞0.05).Compared with Bio-Gide group,the wound healing time and biofilm absorption time were shortened in SIS group(P＜0.05),and the incidence of rejection was decreased 12 d after operation(P＜0.05).CONCLUSIONS:SIS absorbable biofilm and Bio-Gide absorbable biofilm have similar efficacy and safety in repairing GBR for alveolar bone defects,but the former is more biocompatible and the latter can provide longer barrier function.
关键词
牙槽骨缺损修复/小肠黏膜下层可吸收生物膜/Bio-Gide可吸收生物膜/引导骨再生术Key words
Alveolar bone defect repair/Small intestinal submucosa absorbable biological membrane/Bio-Gide ab-sorbable biological membrane/Guided bone regeneration引用本文复制引用
出版年
2024
NETL
NSTL
万方数据