171例颌面部骨软骨瘤及恶变病例临床病理分析
Clincopathological analysis of 171 patients with osteochondroma and malignant transformation in maxillofacial bone
刘丽敏 1孙晶晶 1钱佳骏 1张春叶 1胡宇华 1李江1
作者信息
- 1. 上海交通大学医学院附属第九人民医院 口腔病理科,上海交通大学口腔医学院,国家口腔医学中心,国家口腔疾病临床医学研究中心,上海市口腔医学重点实验室,上海市口腔医学研究所,上海 200011
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摘要
目的:探讨颌面部骨软骨瘤(osteochondroma)的临床及病理特征,总结罕见的骨软骨瘤恶变患者的临床病理特点,为临床诊治提供指导.方法:回顾性收集2018年1月-2023年8月上海交通大学医学院附属第九人民医院手术治疗的171例骨软骨瘤患者,总结分析临床、影像及病理学特点.结果:171例骨软骨瘤患者中,66％(113/171)为女性,34％(58/171)为男性,发病年龄11～76岁,平均44岁.95.3％(163/171)发生于髁突,4％(7/171)发生于冠突,0.5％(1/171)发生于颧弓.98％(159/161)的髁突骨软骨帽厚度小于1 cm.171例骨软骨瘤中,2例(2/171,1.1％)发生恶变,1例恶变为软骨肉瘤(Ⅰ级),1例恶变为高分化骨肉瘤.结论:颌面部骨软骨瘤多发生于女性,以髁突最常见,恶变率为1.1％,与全身其他部位骨软骨恶变率相当.影像学表现对骨软骨瘤恶变的诊断具有重要意义.
Abstract
PURPOSE:To investigate the clinical and pathological features of osteochondroma in maxillofacial region,and to summarize the clinicopathological features of rare osteochondroma malignant transformation in order to provide clin-ical guidance.METHODS:From January 2018 to September 2023,a total of 171 patients with osteochondroma were ret-rospectively collected in Shanghai Ninth People's Hospital,Shanghai Jiao Tong University School of Medicine.Their pre-operative CT and clinicopathological features were analyzed.RESULTS:Of the 171 patients with osteochondroma in maxillofacial bone,66％(113/171)were females and 34％were male.Their age ranged from 11-76 with an average age was 44 years old.Of the 171 cases,95.3％(163/171)in mandible condyle,4％(7/171)in mandible processus coronoideus,and 0.5％(1/171)in zygomatic arch.The imaging findings showed that the thickness of cartilaginous cap was less than 1 cm in 98％(159/161)cases with condyle lesions.Only 2 cases(2/171,1.1％)had malignant transformation.One was diagnosed with secondary chondrosarcoma,another developed low-grade osteosarcoma.CONCLUSIONS:Osteochondroma in max-illofacial region mostly occurs in females,and most commonly located in condylar process,with a malignant change rate of 1.1％,which is similar to that of other parts of the body.Imaging findings have important guiding significance for the diag-nosis of osteochondroma malignant change.
关键词
颌面部/髁突/骨软骨瘤/恶变Key words
Maxillofacial region/Condyle/Osteochondroma/Malignant transformation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据