Objective To compare the clinical efficacy of percutaneous vertebroplasty(PVP)for acute and non-acute osteoporotic vertebral compression fractures(OVCF).Methods The clinical data of 136 patients with osteoporotic thoracolumbar vertebral compression fractures who underwent PVP from January 2021 to December 2021 were retrospectively analyzed,including 80 cases of acute phase(≤2 weeks)and 56 cases of non-acute phase(>2 weeks).Patients were followed up for(15.92±2.78)months(12-21 months).The amount of cement injected,the diffusion and distribution of bone cement,and the cement leakage were recorded in the two groups.The compression ratio of the injured vertebral body(anterior and middle),Cobb angle of the injured vertebral body,visual analogue pain score and Oswestry Disability Index(ODI)were compared between the two groups before and after surgery.Results Both groups successfully completed surgery without spinal nerve injury and other complications.The postoperative recovery of vertebral body height(anterior and middle),Cobb angle,VAS score and ODI score were significantly improved after surgery in both groups(P<0.05).The amount of cement injected,the diffusion and distribution of cement,the recovery of vertebral body height,the visual analogue pain score(VAS)and the change in Oswestry Disability Index(ODI)in the acute group were significantly better than those in non-acute group(P<0.05).The distribution,recovery of vertebral height,improvement of Cobb angle and maintenance of vertebral height and Cobb angle at follow-up in the acute phase group were better than those in the non-acute phase group(P<0.05).The VAS score and ODI score in the acute phase group at final follow-up were also better than those in the non-acute phase group(P<0.05).There were no significant differences in the VAS at 3 d after surgery and bone cement leakage between the two groups(P>0.05).Conclusion Early treatment of osteoporotic thoracolumbar vertebral fracture patients with vertebroplasty can effectively restore and maintain vertebral height,reduce pain,and improve the quality of life of patients.