Objective To investigate the efficacy of transcutaneous auricular vagus nerve stimulation(taVNS)for motor function rehabilitation in patients with ischemic stroke.Methods From June,2023 to October,eighty ischemic stroke patients admitted in the Department of Neurology of Yangzhi Rehabilitation Hospital affiliated to Tongji University were randomly divided into 4 groups with 20 cases in each group.All patients received routine rehabilitation exercise;in addition,patients in different groups received taVNS 0 Hz(control group),30 Hz,300 Hz or 3 000 Hz,respectively.According to the patient's tolerance,the treatment intensity of ta-VNS was 30 min/d for 14 d.The scores of simplified Fugl-Meyer Assessment Extremities(FMA)were evaluated before treatment,30 d and 45 d after treatments.Results There was no significant difference in FMA score among 4 groups before treatment(F=0.195,P=0.900),while the FMA scores 30 d or 45 d after treatment were significantly higher than those before treatment in all groups(P＜0.001).The FMA score of the taVNS 300 Hz group was the best 45 d after treatment(48.81±20.30,P＜0.001).The differences of FMA scores before and 30 d or 45 d after treatment varied significantly among groups(P＜0.001),while the difference of FMA score before and 45 d after treatment in the taVNS 300 Hz group was the largest(9.81±1.69,P＜0.001),which was of clinical significance.Conclusion Transcutaneous auricular vagus nerve stimulation combined with rehabilitation exercise can effectively promote motor function rehabilitation in patients with ischemic stroke,and the effect of taVNS 300 Hz treatment group is the best.
万方数据
维普
