Immunomodulatory role of MDSCs during the neonatal period
Maintaining immune homeostasis is crucial for neonatal health following birth,as neonates encounter the colonization of gut flora and a plethora of external antigens.Myeloid-derived suppressor cells(MDSCs),a group of innate immune cells of myeloid origin with immunosuppressive functions,are known for their significant role in promoting tumor progression.Recent studies,however,have highlighted the critical immunoprotective functions of neonatal MDSCs.Unlike tumor-associated MDSCs,neonatal MDSCs exhibit strong antibacterial activity and play a vital role in preventing inflammatory responses in newborns.This review provides a comprehensive overview of the etiology,characteristics,immunomodulatory functions,and regulatory mechanisms of neonatal MDSCs,emphasizing their role in neonatal inflammatory diseases.This insight aims to provide new strategies for the immunotherapy of neonatal inflammatory diseases.
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