The interaction between the immune system and the nervous system within and across organs has garnered increasing attention in the scientific community.Studies confirm that this interaction manifests not only in research but also in daily life:common symptoms such as swelling and pain during tissue damage or infection result from the mutual interactions between these systems.In conditions such as pneumonia or pulmonary infections,patients often experience symptoms like drowsiness,fatigue,and reduced appetite.The lungs,being vital respiratory organs,facilitate gas exchange through their unique structure and tissues,while also serving as the body's primary defense against pathogen invasion.The immune system and nervous system play pivotal roles in regulating lung function and maintaining homeostasis,influencing the onset and progression of various respiratory diseases.This article emphasizes recent advancements in understanding neuroimmune interactions specifically related to the lungs,aiming to illuminate potential applications for modulating the neuroimmune network in the treatment of respiratory diseases.