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白癜风免疫治疗的研究进展

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白癜风是一种以皮肤色素脱失为主要表现的慢性自身免疫性疾病,对患者生活质量造成严重影响.近年来,针对白癜风的免疫学和分子生物学研究揭示了多个潜在治疗靶点,为疾病的治疗提供了新的策略.本文总结了JAK/STAT通路、PDE-4、Wnt/β-catenin通路和IL-15等新型免疫治疗靶点及其靶向药物的研究进展,旨在为未来白癜风治疗靶点的临床转化提供参考.
The therapeutic targets and clinical translational research in vitiligo
Vitiligo is a chronic autoimmune disease characterized by depigmentation of the skin,significantly impacting patients'quality of life.Recent advances in immunological and molecular biological studies have identified numerous potential therapeutic targets for vitiligo,paving the way for novel treatment strategies.This article reviews the advancements in researching novel immunotherapy targets such as the JAK/STAT pathway,PDE-4,Wnt/β-catenin pathway,and IL-15,along with their respective targeted drugs.The article aims to provide insights into the clinical translation of future therapeutic targets for vitiligo.

VitiligoTherapeutic targetsClinical translationJAK inhibitorsPDE-4 inhibitors

赵柳琦、邹婧、沈清清、佟林荟、杨晴、张越黄、王宏林

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上海交通大学医学院附属上海市第一人民医院疑难疾病精准研究中心,上海 201610

白癜风 治疗靶点 临床转化 JAK抑制剂 PED-4抑制剂

2024

生物医学转化
兰州大学

生物医学转化

CSTPCD
ISSN:2096-8965
年,卷(期):2024.5(2)