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心血管健康行为和因素对中青年人群高血压发病的影响

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目的 旨在探讨理想的心血管健康行为和因素对中青年人群高血压发病的影响.方法 选择2015-2016年在中南大学湘雅三医院完成年度体检的5 372名企事业单位在职人员作为观察队列,随访高血压发病情况,应用多变量Cox比例风险回归模型,校正相关因素后,比较不同理想心血管健康行为和因素人群间高血压的发病风险及累积效应.结果 最终纳入统计的研究对象为4883例,平均年龄(37.80±9.92)岁.平均随访5.33年,有1048例新发高血压患者,累计发病率为21.46%.校正相关危险因素后,不吸烟、理想体重、经常运动、理想血压、理想胆固醇水平者较吸烟、非理想体重、非理想运动状态、非理想血压、非理想胆固醇水平者高血压发病风险分别降低21%(HR=0.79,95%CI 0.69~0.92)、34%(HR=0.66,95%CI 0.58~0.75)、33%(HR=0.67,95%CI 0.58~0.77)、80%(HR=0.20,95%CI 0.17~0.25)和 12%(HR=0.88,95%CI 0.77~0.99).研究对象中具有 0~2、3、4、5和 6~7项理想心血管健康行为和因素者所占比例分别为 14.64%、18.62%、25.76%、28.40%和12.57%,其高血压累积发病率分别为50.35%、32.67%、20.83%、6.99%和5.21%.与具有0~2项理想心血管健康行为和因素者比较,具有3、4、5和6~7项者,新发高血压的风险分别降低33%(HR=0.67,95%CI 0.58~0.79)、57%(HR=0.43,95%CI 0.36~0.51)、82%(HR=0.18,95%CI 0.14~0.23)和85%(HR=0.15,95%CI 0.10~0.21).结论 理想的心血管健康行为和因素是防止高血压发生的保护因素.
Influence of cardiovascular health behaviors and factors on the incidence of hypertension in young and middle-aged population
Objective Aims to investigate the effects of these ideal cardiovascular health behaviors and factors on the incidence of hypertension in young and middle-aged populations.Methods A cohort of 5 372 employed individuals who underwent annual health examinations at The Third Xiangya Hospital of Central South University between 2015 and 2016 was selected for the study.The incidence of hypertension was monitored,and a multivariate Cox proportional hazards regression model was applied.After adjusting for relevant factors,the risks of hypertension and cumulative effects were compared among groups with different ideal cardiovascular health behaviors and factors.Results A total of 4 883 subjects were included in the analysis,with a mean age of(37.80±9.92)years.The average follow-up period was 5.33 years,during which 1 048 new cases of hypertension were identified,resulting in a cumulative incidence rate of 21.46% .After adjusting for relevant risk factors,the risk of developing hypertension was reduced by 21% (HR=0.79,95% CI 0.69-0.92)for non-smokers,34% (HR=0.66,95% CI 0.58-0.75)for those with ideal body weight,33% (HR=0.67,95% CI 0.58-0.77)for regular exercisers,80% (HR=0.20,95% CI 0.17-0.25)for those with ideal blood pressure,and 12% (HR=0.88,95% CI 0.77-0.99)for those with ideal cholesterol levels compared to smokers,those with non-ideal body weight,non-regular exercisers,those with non-ideal blood pressure,and those with non-ideal cholesterol levels.The proportions of study subjects exhibiting 0-2,3,4,5,and 6-7 ideal cardiovascular health behaviors and factors were 14.64%,18.62%,25.76%,28.40%,and 12.57%,respectively,with corresponding cumulative incidence rates of hypertension at 50.35%,32.67%,20.83%,6.99%,and 5.21% .Compared to individuals with 0-2 ideal cardiovascular health behaviors and factors,the risks of developing new hypertension were reduced by 33% (HR=0.67,95% CI 0.58-0.79),57% (HR=0.43,95% CI 0.36-0.51),82% (HR=0.18,95% CI 0.14-0.23),and 85% (HR=0.15,95% CI 0.10-0.21)for those with 3,4,5,and 6-7 ideal behaviors and factors,respectively.Conclusion Ideal cardiovascular health behaviors and other factors were identified as protective against the occurrence of hypertension.

HypertensionCardiovascular health behaviors and factorCohort study

颜磊、李莹、王建刚、杨娉婷

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中南大学湘雅三医院健康管理医学中心,湖南 长沙 410013

中南大学湘雅三医院全科医学科,湖南 长沙 410013

高血压 心血管健康行为和因素 队列研究

2024

生物医学转化
兰州大学

生物医学转化

CSTPCD
ISSN:2096-8965
年,卷(期):2024.5(4)