Objective:To systematically evaluate the clinical efficacy of Baizhu Qiwu Granules combined with acu-puncture on slow transit constipation.Methods:Chinese Biology Medicine(CBM),China National Knowledge Infrastruc-ture(CNKI),PubMed,WanFang,Embase,China Science and Technology Journal Database(CCD)and The Cochrane Library were searched from the establishment of the database to July 2023.Clinical randomized controlled trial(RCT)type research articles were screened and included.Revman 5.0 software was used for data analysis and system assessment,the publication bias was evaluated by Stata 17.0 software,the sequential analysis of trials were performed by TSA 0.9.5 soft-ware,and the outcome indicators were evaluated by Gradepro 3.6 software.Results:A total of 287 patients were included in 4 articles,including 239 in the intervention group and 149 in the control group.The results of meta-subgroup analysis showed that the total clinical effective rate,cure rate and residual number of X-ray markers in the treatment of slow transit constipation with Bazhu Qiwu Granules combined with acupuncture were significantly better than those in the control group,and the differences were statistically significant(RR=1.38,95% CI:1.26～1.52,P<0.01;RR=2.52,95% CI:1.59～3.99,P<0.01;SMD=-2.22,95% CI:-3.23～-1.22,P<0.01).Sensitivity analysis of Stata 17.0 software showed that there was no significant publication bias.The results of TSA 0.9.5 software showed that the conclusion was reliable.Conclusion:Bai-zhu Qiwu Granules combined with acupuncture has a significant clinical effect on slow transit constipation.However,due to the limitation of the quality and sample size of the included literature,it is still necessary to further expand the sample size and conduct multi-center,multi-index and multi-sample clinical randomized controlled trials to verify.
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