Objective:To observe the curative effect of Liu's pediatric tuina school of Xiangxi Miao Medicine"Tui Wu Jing"in the treatment of children with asthma in remission stage and its effect on intestinal flora,and to explore its mechanism.Methods:30 healthy children were selected as the healthy group without any intervention.A total of 60 chil-dren with asthma in remission stage were randomly divided into health education group and tuina group,30 cases in each group.The children in the health education group were given routine intervention and health education,and the children in the tuina group were given pediatric tuina"Tui Wu Jing"on the treatment basis of the health education group,once a day,4 times a week.Both groups were treated for 3 months.The main TCM syndrome scores of the health education group and the tuina group before and after treatment were compared.16S rRNA sequencing technology was used to detect the intesti-nal flora of the two groups after treatment and the healthy group.Results:Compared with those before treatment,the scores of main TCM syndromes such as asthmatic suffocating,chest tightness,cough,shortness of breath and wheezing in the tuina group decreased,and the differences were statistically significant(P<0.05).The scores of main TCM syndromes of asthmatic suffocating and chest tightness in the health education group decreased,and the difference was statistically sig-nificant(P<0.05).Compared with the health education group,the tuina group had significant reductions in the scores of main TCM syndromes such as asthmatic suffocating,chest tightness,cough,shortness of breath,and wheezing after treat-ment(P<0.05).There was a statistically significant difference in the composition of intestinal flora among the three groups(P=0.001).The richness,diversity and evenness of intestinal flora in the health education group were lower than those in the healthy group,and the difference was statistically significant(P<0.05).After treatment,the tuina group had signifi-cantly higher abundance of Coriobacteriia,Coriobacteriales,Coriobacteriaceae,Collinella,Coprococcus,Eubacterium myxoides,SMB53,Lactococcus and 02d 06 than the health education group(LDA>2,P<0.05).Conclusion:The Liu's pe-diatric tuina school of Xiangxi Miao Medicine"Tui Wu Jing"can effectively improve the main TCM syndromes in children with asthma in remission stage,and its mechanism may be related to up-regulating the abundance of beneficial intestinal bacteria and adjusting the intestinal microecology.Upregulation of the abundance of Coriobacteriia,Coriobacteriales and Coprococcus in children with asthma can also provide a reference for pediatric tuina"Tui Wu Jing"to improve the brain dysfunction of children with asthma.
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