Clinical efficacy of Shengxian Decoction combined with nutritional support in the treatment of cachexia of lung cancer
Objective:To evaluate the clinical effect of Shengxian Decoction combined with nutritional support in the treatment of cachexia of non-small cell lung cancer(sinking of pectoral Qi syndrome).Methods:According to the inclu-sion and exclusion criteria,66 cases were selected and randomly divided into control group and treatment group.Due to the shedding of cases during the course,30 cases in each control group and treatment group completed the experiment.Patients in the control group received basic nutritional support therapy,and the patients in the treatment group were given Shengxian Decoction on the treatment basis of the control group.After continuous treatment for 30 days,the changes in body mass,TCM syndrome,anorexia/cachexia status scale score,IL-6 and TNF-alpha,CD4+T cell level and CD4+T/CD8+T were compared between the two groups before and after treatment.Results:(1)After treatment,the average body mass of pa-tients in the treatment group increased by(1.77±1.55)kg,and the average body mass of the patients in the control group increased by(0.45±1.25)kg.The difference between the two groups was statistically significant(P=0.04<0.05).(2)After treatment,the total effective rate of TCM syndrome remission was 63.33%in the treatment group and 36.67%in the control group,and the difference between the two groups was statistically significant(P=0.041<0.05).The relief degree of short-ness of breath and fatigue in the treatment group was better than that in the control group,and the difference was statistically significant(shortness of breath:P=0.026<0.05,fatigue:P=0.009<0.05).(3)After treatment,anorexia/cachexia status scale score(P=0.000<0.01),IL-6(P=0.006<0.01),TNF-ɑ(P=0.002<0.01),CD4+T cell level(P=0.019<0.05),CD4+T/CD8+T(P=0.001<0.01)in the treatment group were significantly better than those of the control group,and the dif-ference was statistically significant.Conclusion:Based on the theory of"sinking of pectoral Qi",Shengxian Decoction combined with nutritional support in the treatment of cachexia of non-small cell lung cancer(sinking of pectoral Qi syn-drome)can effectively relieve the clinical symptoms of patients,improve the nutritional status,reduce the inflammatory re-sponse of the body,and improve the immunity of some patients.
non-small cell lung cancercachexiaShengxian Decoctionsinking of pectoral Qi
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