Objective:To study the difference of liver and kidney toxicity between normal rats and adjuvant arthritis(AA)rats induced by Jingdaji.Methods:SD rats were randomly divided into normal group,normal administration of low,medium and high dose group,AA model group,AA model administration of low,medium and high dose group,and positive group.After continuous gavage for 4 weeks,the effects on the general state,blood biochemical indexes blood creatinine(CREP),UREA nitrogen(UREAL),glutamic-pyruvic transaminase(ALT),glutamic oxalacetic transaminase(AST),organ index and body mass of rats were investigated,and the damage of liver and kidney tissue of rats was observed through patho-logical sections.Results:Compared with the rats in the normal group,the rats in the model group moved less and liked to curl up,but there was no significant change in body mass.After normal administration,the hair of the rats in each group was dull,the skin appeared dark brown,the rats curled up with little movement,the stool was not formed,and the body mass in-creased slowly.The condition of unformed stool was alleviated in rats of all model administration groups,and there was no significant change in body mass.In terms of liver and kidney function,compared with the normal group,there was no statisti-cal significance in AST,ALT,UREA and CREP in the model group and the positive group(P>0.05).After different doses of Jingdaji were given intragastric administration in normal administration group,AST and ALT indexes in all dose groups were significantly increased(P<0.05),and UREAL indexes in high and medium dose groups were significantly increased(P<0.05).In the model administration group,AST and CREP indexes were significantly increased only in the high-dose group(P<0.05).The liver and kidney sections showed that the liver cells of the normal administration group had mild vacuolar de-generation,and the cytoplasm was loose and light dyed.Renal mesangial cells and mesangial matrix were slightly overgrown,and a small amount of eosinophilic substances were seen in the lumen of the renal tubules.The toxicity of Jingdaji to rats un-der normal condition was greater than that under AA model.Conclusion:It can be inferred that the main effect of Jingdaji on AA model rats is therapeutic,while the main effect on normal rats is toxic.Under the guidance of the theory of"Yougu Wuyun",the syndrome differentiation and treatment for applying the Chinese herbal medicines is the premise of safe clinical drug use.
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万方数据
