Meta-analysis of TCM compound formulae combined with sex hormone for treating ovarian function decline
Objective:To systematically evaluate the effectiveness and safety of combined TCM formulae and sex hor-mone therapy for ovarian function decline using meta-analysis,and to understand the efficacy of TCM formulae in treating declining ovarian reserve function.Methods:We searched the China National Knowledge Infrastructure(CNKI),Chinese Science and Technology Periodicals Database(VIP),WANFANG database,Cochrane Library,and PubMed up to January 10,2024,for randomized controlled trials(RCTs)of TCM formulae combined with sex hormone therapy for ovarian function decline.Methodological quality was assessed,and meta-statistical analysis and publication bias assessment were conducted using RevMan 5.4.1 software.Results:A total of 13 RCTs involving 978 patients were included in this study.Compared with the control group,the trial group showed statistically significant improvements in follicle-stimulating hormone(FSH)(SMD=-1.71,95%CI:-2.14 to-1.28),luteinizing hormone(LH)(SMD=-1.60,95%CI:-2.12 to-1.08),estradiol(E2)(SMD=1.26,95%CI:0.49 to 2.02),cure rate(OR=0.40,95%CI:0.27 to 0.61),marked effective rate(OR=0.56,95%CI:0.41 to 0.76),and TCM syndrome efficacy score(OR=3.94,95%CI:3.43 to 4.44).No statistically significant differ-ences were found between the two groups in terms of anti-Müllerian hormone(AMH)(SMD=-0.66,95%CI:-1.50 to 0.18)and effective rate(OR=1.25,95%CI:0.93 to 1.69).Conclusion:The combination of TCM formulae and sex hormone therapy is safe and effective in the treatment of ovarian function decline,particularly in regulating sex hormone levels and improving clinical symptoms.
TCM compound formulaeovarian function declinesex hormone therapyMeta-analysis
万方数据
维普
