Exploration of the medication rules of Chinese herbal compound in the treatment of hepatic fibrosis based on data mining technology
Objective:To study the medication rules of Chinese herbal compound in the treatment of hepatic fibrosis by data mining technology,in order to provide guidance and reference for the clinical treatment of hepatic fibrosis.Meth-ods:On the topic of hepatic fibrosis,the literature included in China National Knowledge Infrastructure(CNKI),Wanfang Database and VIP Chinese Science and Technology Journal database were collected and sorted out as the data source of this study,and a database was established.Excel 2019,SPSS Statistics 22.0 and IBM SPSS Modeler 18.0 software were used for frequency analysis,association rule analysis,factor analysis and systematic cluster analysis.Data mining was carried out for the compounds that met the inclusion criteria of this study.Results:Among the 134 Chinese herbal compounds that met the inclusion criteria,159 Chinese herbs were involved,and the total frequency of administration was 1437 times.There were 31 Chinese herbs used more than or equal to 10 times,and the most commonly used single herb was Danshen.The four na-tures were mainly cold and warm,the five flavors were mostly bitter,sweet and pungent,and the herbs were mostly attrib-uted to the liver and spleen channels.The analysis of drug frequency indicated that the top 3 drug categories were deficiency-tonifying drugs,blood-activating drugs for removing blood stasis drugs and heat-clearing drugs.Association rule analysis showed that there were 8 groups of couplet medicines with the highest association strength,11 common factors were extracted by factor analysis,and 6 categories were classified by systematic cluster analysis.The complex network analysis showed that the core prescription was Danshen,Chishao,Biejia,Huangqi,Baizhu,Baishao,Chaihu and Danggui.Con-clusion:The basic treatment methods of TCM for hepatic fibrosis are promoting blood circulation and removing blood sta-sis,regulating Qi and strengthening healthy Qi,and clearing heat and removing dampness.The core prescription has refer-ence significance for TCM treatment of hepatic fibrosis.
万方数据
维普
