Analysis of the correlation between TCM syndrome elements and risk factors in 958 cases of chronic obstructive pulmonary disease in high-risk groups
Objective:To investigate the correlation between TCM syndrome elements and risk factors in a high-risk population for chronic obstructive pulmonary disease(COPD).Methods:Baseline data,TCM syndromes,and related risk factors were randomly surveyed in 958 individuals at high risk for COPD.The distribution of TCM syndrome elements was explored,and the correlation between TCM syndrome elements and risk factors was analyzed using binary logistic regres-sion.Results:Out of 958 subjects,184 had no syndrome,and 774 had one or more syndromes.The three most common syndromes were lung-kidney Qi deficiency,lung-Qi deficiency,and phlegm-dampness obstructing the lung.The distribu-tion of pathological syndrome elements was as follows:Qi deficiency>phlegm>dampness>Yin deficiency>blood stasis>heat>Yang deficiency.The distribution of location-related syndrome elements was:lung>kidney>spleen>spirit.There were 674 males and 284 females.Age distribution:40-49 years(73 cases),50-59 years(361 cases),60-69 years(390 cases),and 70-79 years(134 cases),with the highest prevalence in the 50-69 age group.In both genders,the most common syndrome elements in the main age groups were Qi deficiency,phlegm,dampness,lung,and kidney.Logistic regression analysis showed that female gender was an independent protective factor for phlegm,dampness,and lung(P<0.05);age was an in-dependent risk factor for Qi deficiency(P<0.05);smoking history was an independent risk factor for Qi deficiency,phlegm,dampness,Yin deficiency,blood stasis,heat,lung,kidney,spleen(P<0.05);secondhand smoke exposure was an inde-pendent risk factor for Qi deficiency,phlegm,dampness,and lung(P<0.05);a family history of asthma,chronic bronchi-tis,or emphysema was an independent risk factor for Qi deficiency,phlegm,Yin deficiency,heat,lung,and kidney(P<0.05);a history of chronic respiratory disease was an independent risk factor for Qi deficiency,phlegm,dampness,lung,and kidney(P<0.05);a family history of COPD was an independent risk factor for phlegm(P<0.05);repeated lower respira-tory tract infections in childhood were independent risk factors for blood stasis,heat,and spirit(P<0.05).Conclusion:In the high-risk population for COPD,the predominant pathological syndrome elements were Qi deficiency,phlegm,and dampness,and the predominant location-related syndrome elements were lung,kidney,and spleen.Males in this high-risk population were more prone to phlegm,dampness,and lung-related pathological changes,while older age was associ-ated with Qi deficiency.Smoking history was linked to Qi deficiency,phlegm,dampness,Yin deficiency,blood stasis,lung,kidney,spleen,and heat-related pathological changes.Secondhand smoke exposure was associated with Qi defi-ciency,phlegm,dampness,and lung-related pathological changes.A family history of asthma,chronic bronchitis,or em-physema was linked to Qi deficiency,phlegm,Yin deficiency,heat,lung,and kidney-related pathological changes.A his-tory of chronic respiratory disease was associated with Qi deficiency,phlegm,dampness,lung,and kidney-related patho-logical changes.A family history of COPD was linked to phlegm-related pathological changes.Repeated lower respiratory tract infections in childhood were associated with blood stasis,heat,and spirit-related pathological changes.
万方数据
维普
