首页|清热降逆法治疗胃食管反流病疗效的Meta分析

清热降逆法治疗胃食管反流病疗效的Meta分析

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目的:评价清热降逆法治疗胃食管反流病的临床疗效.方法:通过检索中国知网(CNKI)、万方数据库(WANFANG)、维普数据库(VIP)、中国生物医学数据库(SinoMed)及PubMed、Cochrane Library等数据库,收集建库至2023年10月发表的清热降逆法治疗胃食管反流病的临床随机对照试验(RCT)文献,使用RevMen 5.3软件进行Meta分析.结果:共纳入15篇文献,包含1199例患者.Meta分析结果表明清热降逆法试验组的临床总有效率[RR=1.20,95%CI(1.15,1.27),Z=7.34,P<0.000 01]和内镜有效率[RR=1.14,95%CI(1.04,1.26),Z=2.76,P=0.006]均优于常规西药对照组,复发率[RR=0.30,95%CI(0.14,0.65),Z=3.06,P=0.002]低于常规西药对照组,差异有统计学意义(P<0.05).结论:清热降逆法治疗胃食管反流病有较好的临床疗效,但纳入文献质量较低,仍需依靠高质量、大样本、多中心的研究进行进一步验证.
Meta-analysis of the curative effect of clearing heat and lowering the adverse flow of Qi therapy on gastroesophageal reflux disease
Objective:To evaluate the clinical curative effect of clearing heat and lowering the adverse flow of Qi therapy on gastroesophageal reflux disease.Methods:By searching CNKI,WANFANG,VIP,SinoMed,PubMed,Co-chrane Library and other databases,the clinical randomized controlled trials(RCTS)of clearing heat and lowering the ad-verse flow of Qi therapy on gastroesophageal reflux disease published from the establishment of the database to October 2023 were collected.RevMen 5.3 software was used for Meta-analysis.Results:A total of 15 studies involving 1199 patients were included.Meta-analysis results show that clinical total effective rate of experimental group of clearing heat and lowering the adverse flow of Qi therapy(RR=1.20,95%CI(1.15,1.27),Z=7.34,P<0.000 01)and endoscopic effective rate[RR=1.14,95%CI(1.04,1.26),Z=2.76,P=0.006]were better than those of conventional western medicine control group,and the re-currence rate[RR=0.30,95%CI(0.14,0.65),Z=3.06,P=0.002]was lower than that of the conventional western medicine control group,with the statistical significance(P<0.05).Conclusion:The treatment of gastroesophageal reflux disease with clearing heat and lowering the adverse flow of Qi therapy has good clinical effect,but the quality of the included literature is low.Therefore,further verification is still needed by high-quality,large sample and multi-center studies.

gastroesophageal reflux diseaseclearing heat and lowering the adverse flow of Qi therapyRCTSMeta study

陆家颖、黄适、方威龙、刘俏涓、林学敏、曾繁钦、苏子豪

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广西中医药大学,广西 南宁 530001

广西中医药大学附属瑞康医院,广西 南宁 530011

胃食管反流病 清热降逆法 随机对照试验 Meta研究

国家自然科学基金地区项目

82060845

2024

山西中医药大学学报

山西中医药大学学报

ISSN:
年,卷(期):2024.25(8)