Observation of clinical efficacy of Qijiao Tongluo Washing Lotion for diabetic peripheral neuropathy with Yang deficiency and blood stasis syndrome
Objective:To investigate the clinical efficacy of Qijiao Tongluo Washing Lotion in treating diabetic pe-ripheral neuropathy(DPN)with Yang deficiency and blood stasis syndrome.Methods:Sixty-eight patients with DPN and Yang deficiency and blood stasis diagnosed in the First Affiliated Hospital of Anhui University of Chinese Medicine from July 1,2022 to July 1,2023 were randomly assigned to the control group and the treatment group,with 34 patients in each group.The treatment group was treated with Qijiao Tongluo Washing Lotion,Epalrestat tablets and basic therapy,while the control group was treated with Qijiao Tongluo Washing Lotion simulant,Epalrestat tablets and basic therapy,with one course of treatment lasting for two weeks.The outcome indicators included total effective rate,TCSS score,MNSI question-naire score,MNSI physical examination score,bilateral common fibular nerve and peroneal nerve electromyography,blood glucose level,liver and kidney function,and incidence of adverse reactions.Results:The overall effective rate was signifi-cantly higher in the treatment group compared to the control group(P=0.036).There were no significant differences in liver and kidney functions or the incidence of adverse reactions between the two groups(P>0.05).After treatment,compared to the control group,the treatment group showed statistically significant improvements in TCSS scores,MNSI questionnaire scores,MNSI physical examination scores,the reduction of fasting and 2-hour postprandial blood glucose levels,the in-crease of conduction velocity and wave amplitude level of the common fibular nerve and peroneal nerve,as well as the short-ening of latency(P<0.05,P<0.01).Conclusion:Qijiao Tongluo Washing Lotion can significantly improve the clinical symptoms of DPN patients,improve the nerve conduction function,enhance the therapeutic efficacy,and has a good safety.
万方数据
维普
