Reduced risk of readmission in patients with hypercoagulable state of osteoarthritis by traditional Chinese medicine treatment:a population-based retrospective cohort study
Objective:To analyze the effect of traditional Chinese medicine treatment on readmission of patients with hypercoagulable state(HS)of osteoarthritis(OA).Methods:The data of 3929 OA patients in the rheumatology depart-ment of the First Affiliated Hospital of Anhui University of Chinese Medicine were collected and followed up by telephone.A retrospective cohort study was conducted using propensity score matching(PSM).Kaplan-Meier curve was used to analyze the effects of HS and traditional Chinese medicine intervention on the readmission of OA patients.Logistic regression model was used to evaluate the risk factors of readmission in OA patients with HS.Data mining was used to observe the effects of Chinese herbal treatment on clinical laboratory indicators(ESR,hs-CRP,APTT,PT,TT,PLT and FBG)and readmis-sion in OA patients with HS.Results:According to inclusion and exclusion criteria,3747 patients with OA were finally in-cluded in this study,among which the incidence of HS was 25.54%(957/3747).After 1∶1 matching,928 OA patients with HS and 928 OA patients with non-HS were finally included,and they were divided into OA-HS group and OA-non-HS group.The OA-HS group was then divided into CHM group(364 cases)and Non-CHM group(564 cases)according to whether Chinese herbal medicines were used or not.The results showed that the readmission rate of OA-HS group was higher than that of OA-non-HS group,and the difference was statistically significant(P<0.01).The readmission rate of CHM group was significantly lower than that of Non-CHM group,and the difference was statistically significant(P<0.01).Kaplan-Meier survival curve and logistic regression model analysis showed that Chinese herbal medicine was an indepen-dent protective factor for readmission in OA patients with HS,while ESR,APTT and FBG were risk factors.Retrospective data mining showed that Chinese herbal medicine treatment could effectively improve inflammation(ESR and hs-CRP)and coagulation indexes(APTT,FBG and PLT)in OA patients with HS.Association rule analysis found that there was a strong correlation between Honghua,Jixueteng,Chenpi and Weilingxian and non-readmitted OA patients with HS.Conclusion:The risk of readmission for OA patients with HS is higher than that for OA patients with non-HS.As a protective factor,Chi-nese herbal medicine treatment can improve inflammation and coagulation indexes in OA patients,thereby reducing the risk of readmission in OA patients with HS.
万方数据
维普
