Clinical study of Tiaoshen Hewei Formula combined with deanxit in the treatment of functional dyspepsia due to liver-stomach disharmony
Objective:To investigate the efficacy of Tiaoshen Hewei Formula combined with deanxit in the treatment of functional dyspepsia(FD)due to liver-stomach disharmony,as well as its effects on glutamate(Glu),γ-aminobutyric acid(GABA)expression level,emotional state,and gastrointestinal motility in patients with the disease.Methods:A total of 96 patients diagnosed with FD due to liver-stomach disharmony after syndrome differentiation were randomly divided into ob-servation group and control group,with 48 cases in each group.The observation group finally completed the clinical treat-ment of 45 cases(3 cases dropped off),and the control group finally completed the clinical treatment of 44 cases(4 cases dropped off).In terms of treatment plan,patients in the control group were treated with deanxit,and patients in the observa-tion group were treated with Tiaoshen Hewei Formula on the treatment basis of the control group.The treatment period was 4 weeks.The TCM syndrome score,Hamilton Anxiety Scale(HAMA)score,Hamilton Depression Scale(HAMD)score of the two groups were evaluated before and after treatment.The expression levels of Glu,GABA and 5-hydroxytryptamine(5-HT)in peripheral blood serum were measured.Motilin(MTL)level,gastrin(GAS)level andthe occurrence of clinical adverse re-actions were measured.Results:After treatment,each TCM syndrome score(abdominal fullness or pain,lateral thorax full-ness,emotional fluctuation,belching,dry mouth and bitter mouth),anxiety and depression scores,and the levels of Glu and 5-HT in peripheral blood serum in the observation group were significantly decreased,which were lower than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in acid reflux and heartburn syndrome score(P>0.05).The levels of GABA,MTL and GAS in peripheral blood serum in the observation group were significantly increased,which were higher than those in the control group,the difference was statistically significant(P<0.05).The total effective rate was 84.4%(38/45)in the observation group and 63.64%(28/44)in the control group,and the difference was statistically significant(P<0.05).Conclusion:Tiaoshen Hewei Formula combined with deanxit can effec-tively improve the clinical symptoms of FD patients due to liver-stomach disharmony,and it is worth promoting.
万方数据
维普
