Exploration of the medication and compatibility rules of Chinese herbs for treating otitis media with effusion based on data mining
Objective:To explore the compatibility rules of Chinese herbs for treating otitis media with effusion(OME),and to provide theoretical references for clinical medication and new drug development for the disease in the early stage.Methods:A database was established by searching the clinical research literature on OME treated by Chinese herbal compound and integrated Chinese and Western medicine in CNKI.The included data were subjected to statistical analysis for medication frequency,properties,flavors and channel tropism throug the Ancient and Modern Medical Case Cloud Plat-form.The complex network,association rules and cluster analysis of Chinese herbs were also carried out.Results:162 Chi-nese herbs were included in 258 prescriptions,among which the high-frequency drugs were Gancao,Changpu,Fuling,Chaihu and so on.The properties of the herbs were mainly neutral,warm,and cold,and the flavors were predominantly pungent,sweet,and bitter.The meridians mainly involved were the lung,spleen,and liver meridians.The main effects were clearing damp and promoting diuresis,soothing the liver and relieving depression and alleviating pain to expel wind.Complex network analysis revealed a core prescription composed of 9 herbs including Changpu,Fuling,Gancao,Chaihu,Chuanxiong,Jiegeng,Chenpi,Baizhu and Zexie.Association rule analysis identified 8 sets of common drug pairs for OME,namely Chuanxiong-Chaihu,Jiegeng-Gancao,Chenpi-Fuling,Xiangfu-Chaihu,Baizhu-Fuling,Xiangfu-Changpu,Xiangfu-Chuanxiong and Banxia-Fuling,among which"Chaihu-Chuanxiong"had the highest support.4 clusters were ob-tained by cluster analysis.Cluster 1:Gancao;Cluster 2:Jiegeng,Fuling and Chenpi;Cluster 3:Baizhu and Zexie;Clus-ter 4:Changpu,Chaihu,Chuanxiong and Xiangfu.The results of cluster analysis showed that modified Erchen Decoction,Zexie Decoction and Tongqi Powder were the most commonly used formulas in the treatment of OME by different doctors,which followed the therapeutic principles of dispelling wind and ventilating lung to regulate the waterway,tonifying spleen to transport water-dampness,clearing damp and promoting diuresis and soothing liver and promoting Qi circulation to regu-late Qi activity.Conclusion:Ancient and modern medical practitioners often treat OME from the lung,spleen,and liver,focusing on resolving exterior conditions and ventilating the lung,strengthening the spleen and resoving dampness,as well as dispersing stagnated liver Qi to relieve depression,promoting circulation of Qi and freeing orifices as the main treatment principles.This provides a theoretical basis for the development of new Chinese herbs in clinical practice.
OMEcompatibility rulesAncient and Modern Medical Case Cloud Platformdata mining
万方数据
维普
