Effect of Modified Huangxiong Antithrombotic Formula on serum inflammatory factors hs-CRP and IL-6 levels in patients with post-stroke depression
Objective:To observe the effect of Modified Huangxiong Antithrombotic Formula on serum inflammatory factors high-sensitivity C-reactive protein(hs-CRP)and interleukin-6(IL-6)levels in patients with post-stroke depression(PSD).Methods:Sixty-two PSD patients admitted to the Department of Encephalopathy of the Geriatric Center at the First Affiliated Hospital of Anhui University of Chinese Medicine(Anhui Provincial Hospital of Traditional Chinese Medicine)between December 1,2022,and December 1,2023,were randomly divided into a control group and an observation group,with 31 patients in each group.Patients in both groups received conventional treatment.Patients in the control group took es-citalopram oxalate tablets orally,10 mg/time,1 time/day.Patients in the observation group took Modified Huangqiong Anti-thrombotic Formula in addition to the treatment given to the control group.Patients in both groups were treated for four weeks.After four weeks,changes in serum hs-CRP and IL-6 levels,as well as NIH Stroke Scale(NIHSS),Hamilton De-pression Rating Scale(HAMD),Modified Barthel Index(MBI),and Pittsburgh Sleep Quality Index(PSQI)scores were ob-served.Results:After treatment,serum hs-CRP and IL-6 levels,as well as NIHSS,HAMD,and PSQI scores decreased,while MBI scores increased in both groups,with statistically significant differences(P<0.01).After treatment,serum hs-CRP and IL-6 levels,as well as NIHSS,HAMD,and PSQI scores were lower in the observation group compared to those of the control group,while MBI scores and overall effective rates were higher,with statistically significant differences(P<0.05,P<0.01).There was no statistically significant difference in adverse reaction rates between the two groups(P>0.05).Conclusion:The Modified Huangxiong Antithrombotic Formula can reduce serum inflammatory factor levels in patients with PSD,alleviate depressive symptoms,improve daily living abilities,and reduce the frequency of bad moods.It has minimal adverse reactions and good therapeutic effects,making it suitable for clinical use.
万方数据
维普
