首页|抗生素骨水泥诱导膜技术联合祛腐生肌膏治疗糖尿病足溃疡30例临床观察

抗生素骨水泥诱导膜技术联合祛腐生肌膏治疗糖尿病足溃疡30例临床观察

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目的:观察抗生素骨水泥诱导膜(PMMA)技术联合祛腐生肌膏治疗糖尿病足溃疡(DFUs)的临床疗效.方法:将60例Wagner分级3~4级的DFUs患者随机分为治疗组和对照组,每组30例.治疗组采用清创+PMMA技术+祛腐生肌膏治疗,对照组采用清创+负压封闭引流技术(VSD)+祛腐生肌膏治疗,6周后比较两组患者的创面溃疡面积、肉芽组织面积、治疗费用、住院时间、创面愈合时间以及总有效率.结果:与治疗前比较,两组患者治疗6周后溃疡面积明显减小,肉芽组织面积明显增多,差异有统计学意义(P<0.01);与对照组比较,治疗组患者溃疡面积减少,肉芽组织面积增多,住院时间、创面愈合时间缩短,治疗费用降低,总有效率(96.67%)高于对照组(76.67%),差异均有统计学意义(P<0.05,P<0.01).结论:抗生素骨水泥诱导膜技术联合祛腐生肌膏治疗DFUs有较好的临床疗效,在缩小创面溃疡面积、促进创面肉芽组织增生方面效果明显,且能缩短创面愈合时间及住院时间,减少治疗费用,值得临床推广应用.
Clinical observation on 30 cases of diabetic foot ulcers treated with polymethyl methacrylate technique combined with Qufu Shengji Paste
Objective:To observe the clinical efficacy of the polymethyl methacrylate(PMMA)technique combined with Qufu Shengji Paste in the treatment of diabetic foot ulcers(DFUs).Methods:Sixty patients with Wagner grade 3-4 DFUs were randomly divided into a treatment group and a control group,with 30 cases in each group.Patients in the treat-ment were treated with debridement,PMMA technique and Qufu Shengji Paste,while patients in the control group were treated with debridement,vacuum sealing drainage(VSD)technique and Qufu Shengji Paste.After six weeks,traumatic ul-cer area,granulation tissue area,treatment costs,hospital stay,wound healing time,and overall effective rate were com-pared between the two groups.Results:Compared with before treatment,after six weeks both groups showed significantly reduced ulcer areas and increased granulation tissue areas and the difference was statistically significant(P<0.01).Com-pared with the control group,the treatment group had a smaller ulcer area,more granulation tissue,shorter hospital stay and wound healing time,lower treatment costs,and a higher overall effective rate(96.67%),with statistically significant differences(P<0.05,P<0.01).Conclusion:PMMA technique with Qufu Shengji Paste has good clinical efficacy in treating DFUs.It is particularly effective in reducing ulcer size,promoting granulation tissue growth,shortening wound healing time and hospital stay,and reducing treatment costs.This approach is worthy of clinical promotion and application.

diabetic footDFUsPMMAQufu Shengji Paste

蒋绍柱、唐新宁、王燃峰、聂禄明、雷剑文

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永州市中医医院,湖南 永州 425000

糖尿病足 糖尿病足溃疡 抗生素骨水泥 祛腐生肌膏

2024

山西中医药大学学报

山西中医药大学学报

ISSN:
年,卷(期):2024.25(11)