Discussion on the diagnosis and treatment of Wilson's disease with depression based on the"microbe-brain-gut axis"theory
Wilson's disease(WD)is a genetic disorder of copper metabolism due to autosomal recessive gene mutations,often affecting multiple organs and systems,with complex clinical manifestations.According to Chinese medicine,the funda-mental cause of this disease is congenital insufficiency and internal accumulation of copper toxicity.The pathogenesis is reten-tion of damp-heat in the interior and intermin-gled phlegm and blood stasis.Treatment principles include tonifying the liver and kidneys,clearing heat and draining dampness,resolving phlegm and eliminating stasis,as well as removing toxin and draining copper,with notable clinical efficacy.Patients with WD frequently suffer from depression,which severely affects their daily work and life.In recent years,with the rapid development of theories and research related to the microbe-brain-gut axis,an increasing number of studies have pointed out that the microbe-brain-gut axis is a complex mechanism involving bidirec-tional regulation between the central nervous system and the gastrointestinal tract,which has significant implications for the treatment of mental disorders.Chinese medicine and acupuncture treatments improve clinical symptoms in patients with WD and depression by modulating the function of the microbe-brain-gut axis,providing new insights into the clinical diagnosis and treatment of WD with depression.
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