肿瘤中M2型丙酮酸激酶的表达、功能及调节
Expression, functions and regulation of PKM2 in tumor cells
时蒙昆 1时雨 1王群1
作者信息
- 1. 复旦大学附属中山医院胸外科 上海200032
- 折叠
摘要
高水平的糖酵解是癌细胞的重要特征之一,而其中一个重要的调节因子即M2型丙酮酸激酶(M2 typeof pyruvate kinase,PKM2).除此之外,PKM2还具有调控基因转录以及细胞周期进展、促进肿瘤形成和侵袭迁移等蛋白激酶活性.同时,PKM2受多种转录因子、癌基因蛋白和中间代谢产物等复杂因素的调控.大量研究表明,PKM2在肿瘤的发生进展过程中起着至关重要的作用,针对PKM2展开相应临床诊断和治疗研究有着良好的应用前景.
Abstract
M2 type of pyruvate kinase (PKM2) is one of the most important regulatory molecules in glycolysis,which at high level is a major feature of tumor cells.Besides,PKM2 also regulates gene transcription and cell cycle,promoting the formation,invasion and migration of tumors.Meanwhile,PKM2 can beregulated by many transcription factors,oncogene proteins,miRNA and intermediate metabolites.Extensive studies indicated that PKM2 plays an important role in the developmental tumor.In view of the significance of PKM2 in tumor cells,it holds promise for diagnosis and treatment benefits.
关键词
M2型丙酮酸激酶/肿瘤代谢/转录水平Key words
M2 type of pyruvate kinase/tumor metabolism/transcrptional level引用本文复制引用
基金项目
国家自然科学基金(81401875)
国家自然科学基金(81472225)
上海市自然科学基金(14ZR1406000)
出版年
2017
NETL
NSTL
维普
万方数据