Research progress on key signaling pathways of alveolar epithelial cell transdifferentiation in the pathogenesis of bronchopulmonary dysplasia
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维普
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支气管肺发育不良(bronchopulmonary dysplasia,BPD)是早产儿严重呼吸系统并发症,重症病例仍缺乏有效治疗手段.BPD是多因素疾病,发病机制主要包括肺泡简单化和肺微血管发育障碍.肺泡上皮细胞是肺泡的主要构成部分,包括肺泡Ⅰ型(alveolar type 1,AT1)和肺泡Ⅱ型(alveolar type 2,AT2)细胞,其中AT1细胞参与气血屏障构建,发挥气体交换作用,AT2细胞具有增殖分化的干细胞特性,维持肺内环境稳态、修复肺损伤.肺损伤修复的核心是AT2细胞向AT1细胞的转分化,而激活转分化的信号转导机制尚未明确.本文通过文献检索和分类总结,探讨肺泡上皮细胞转分化的关键信号转导通路及研究进展,为阐述BPD发病机制及探索BPD新的治疗方案提供参考.
Bronchopulmonary dysplasia(BPD)is a detrimental respiratory complication associated with prematurity that still lacks effective treatment.BPD is a multifactorial disease with a pathogenesis involving alveolar simplification and impaired vascularization.Alveolar epithelial cells are the main components of alveoli including alveolar type Ⅰ(AT1)and alveolar type Ⅱ(AT2)epithelial cells.AT1 cells are involved in constructing the air-blood barrier and facilitating gas exchange,while AT2 cells,characterized by proliferative and differentiated stem cell properties,maintain lung homeostasis and contribute to lung injury.The transdifferentiation of AT2 cells into AT1 cells is a core mechanism in the repair of lung injuries,although the key signaling pathway activating transdifferentiation remains unclear.This article introduces the key signaling pathways and research progress in alveolar epithelial cell transdifferentiation through literature retrieval and classification summary,providing a foundation for elucidating the pathogenesis of BPD and exploring new therapeutic regimens for BPD.
维普
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