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宫颈腺样囊性癌6例报道及文献回顾

Adenoid cystic carcinoma of the cervix:6 cases report and literature review

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宫颈腺样囊性癌(adenoid cystic carcinoma,ACC)是一种罕见且高度侵袭性的宫颈癌亚型,发病率不到所有宫颈癌的1%.该疾病多见于60岁以上的绝经期女性,常以绝经后阴道出血为主要症状,其诊断主要依赖于组织病理学和免疫组化分析.尽管目前尚无标准治疗方案,手术切除结合放疗或同步放化疗被认为是ACC较为有效的治疗方式,但疗效有限,尤其是在晚期病例中预后较差.ACC的治疗和预后与肿瘤分期、神经周围侵犯及切缘状态密切相关.本文对复旦大学附属妇产科医院治疗的6例ACC患者的临床资料和随访情况进行总结,并结合文献复习,探讨其临床特点和治疗经验,强调了早期诊断和个体化治疗的重要性.
Adenoid cystic carcinoma(ACC)of the cervix is a rare and highly aggressive subtype of cervical cancer,accounting for less than 1%of all cervical cancer cases.ACC predominantly affects postmenopausal women over the age of 60,with postmenopausal vaginal bleeding being the most common symptom.Diagnosis of ACC primarily relies on histopathological examination and immunohistochemical analysis.Although there is currently no standard treatment protocol,surgical resection combined with radiotherapy or concurrent chemoradiotherapy is considered to be an effective approach.However,the effectiveness is limited,particularly in advanced cases,which generally have a poor prognosis.The treatment and prognosis of ACC are closely related to tumor staging,perineural invasion,and margin status.This paper discusses the clinical data and follow-up of six ACC patients treated at our institution,and goes through a literature review,examines its clinical features and treatment outcomes,underscores the critical importance of early diagnosis and individualized treatment.

adenoid cystic carcinoma(ACC)cervical cancercervixtreatment

姜婷、龚滢欣、马淼、徐言、周加敏、丁景新、刘晓霞

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复旦大学附属妇产科医院长三角一体化示范区青浦分院妇科 上海 201713

复旦大学附属妇产科医院妇科 上海 200011

上海市女性生殖内分泌相关疾病重点实验室 上海 200011

腺样囊性癌(ACC) 宫颈癌 宫颈 治疗

2025

复旦学报(医学版)
复旦大学

复旦学报(医学版)

北大核心
影响因子:1.206
ISSN:1672-8467
年,卷(期):2025.52(1)