复旦学报(医学版)2025,Vol.52Issue(1) :147-152.DOI:10.3969/j.issn.1672-8467.2025.01.021

肺泡灌洗液外观不典型肺泡蛋白沉积症1例报告并文献复习

Pulmonary alveolar proteinosis with atypical bronchoalveolar lavage fluid appearance:a case report and literature review

剧素贞 王祥 赵开顺 余艳芳 屠春林
复旦学报(医学版)2025,Vol.52Issue(1) :147-152.DOI:10.3969/j.issn.1672-8467.2025.01.021

肺泡灌洗液外观不典型肺泡蛋白沉积症1例报告并文献复习

Pulmonary alveolar proteinosis with atypical bronchoalveolar lavage fluid appearance:a case report and literature review

剧素贞 1王祥 2赵开顺 1余艳芳 1屠春林1
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作者信息

  • 1. 上海健康医学院附属嘉定区中心医院呼吸与危重症医学科 上海 201800
  • 2. 复旦大学附属中山医院病理科 上海 200032
  • 折叠

摘要

肺泡蛋白沉积症(pulmonary alveolar proteinosis,PAP)是一种罕见的肺部进行性呼吸功能障碍性疾病,起病隐匿,临床表现缺乏特异性,常被误诊误治.现报道1例嘉定区中心医院收治的肺泡灌洗液外观不典型的PAP患者,经皮下注射重组人粒细胞-巨噬细胞集落刺激因子(granulocyte macrophage-colony stimulating factor,GM-CSF)治疗后病情明显好转,并结合相关文献以加分析讨论,以加深对这种疾病及其疗法的认识.

Abstract

Pulmonary alveolar proteinosis(PAP)is a rare progressive respiratory dysfunction disease of the lung characterized by insidious onset and non-specific clinical manifestations,often leading to misdiagnosed and mistreated.Herein,we reported a case of PAP patient admitted to Jiading District Central Hospital with an atypical appearance of alveolar lavage fluid and whose condition improved significantly after treatment with subcutaneous injection of recombinant human granulocyte-macrophage colony stimulating factor(GM-CSF).Additionally,we have reviewed and summarized the relevant literature to enhance the understanding of the diagnosis and treatment of this disease.

关键词

肺泡蛋白沉积症(PAP)/粒细胞-巨细胞集落刺激因子(GM-CSF)/肺泡灌洗液

Key words

pulmonary alveolar proteinosis(PAP)/granulocyte-macrophage colony stimulating factor(GM-CSF)/alveolar lavage fluid

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出版年

2025
复旦学报(医学版)
复旦大学

复旦学报(医学版)

CSCD北大核心
影响因子:1.206
ISSN:1672-8467
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