首页|上海市某区域老年群体轻度认知功能障碍的发生情况及其影响因素分析

上海市某区域老年群体轻度认知功能障碍的发生情况及其影响因素分析

Prevalence and related factors of mild cognitive impairment among elderly people in a certain area of Shanghai

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目的 分析上海市嘉定区嘉定镇60岁及以上老年人轻度认知功能障碍(MCI)的发生情况,探究影响MCI发生的相关因素,为制订MCI人群的干预措施提供理论依据.方法 本研究采用横断面调查研究的方法,选取2020年5-7月在上海市嘉定区嘉定镇社区卫生服务中心参加健康体检的60岁及以上老年人群,共4 962人.根据纳排标准,应用简单随机抽样的方法,共抽取目标人数860人.其中,48人拒绝接受调查或部分调查,接受全部调查者为812人.采用问卷调查收集受试者的基本信息、人口学资料、慢性病类型、生活行为方式等.根据Petersen标准,结合蒙特利尔认知评估基础量表(montreal cognitive assessment basic,MoCA-B 量表)、日常生活能力量表(activity of daily living scale,ADL)、临床痴呆量表(clinical dementia rating scale,CDR)评估受试者MCI发生情况.受试者的MCI由精神卫生中心精神科医师进行最后确诊.计算MCI的发生率,观察MCI发生的影响因素.结果 在接受全部调查的812人中,收回有效问卷791份,有效率97.41%.根据Petersen标准,在791人中,符合MCI诊断标准192人,认知正常者563人,共755人纳入分析.对于60岁及以上受试者,随年龄增长,MCI发生率显著增高(x2=19.120,P<0.01);当受试者教育年限≤12年时,MCI发生率随着教育年限的延长而显著降低,而当教育年限>12年时,受试者的MCI发生率显著增高(x2=21.670,P<0.01);子女数越多,MCI发生率越高,差异有统计学意义(x2=11.460,P<0.01);与以脑力劳动为主的受试者相比,以体力劳动为主的受试者MCI发生率显著增高(x2=22.110,P<0.01).中心型肥胖的受试者MCI发生率较非中心型肥胖的受试者显著增高(x2=4.661,P=0.031).有糖尿病的受试者MCI发生率显著高于无糖尿病者(x2=6.012,P=0.014);有忌口、仍在吸烟的受试者的MCI发生率较无忌口、不吸烟或已戒烟者显著增高(x2=7.807、44.555,P=0.005或<0.001),而会说外语、锻炼频率高的受试者MCI发生率较不会说外语、锻炼频率低者显著降低(x2=3.962、17.014,P=0.047、0.001).将上述单因素分析中有统计学意义的变量(年龄、教育年限、子女数、职业属性、中心型肥胖、糖尿病、有忌口、吸烟、会外语、锻炼频率)作为自变量,是否发生MCI作为因变量,进行二元logistic回归分析;结果 显示,以体力劳动为主(OR=2.525,95%CI 为 1.618~3.939,P<0.001)、有忌口(OR=1.529,95%CI 为 1.045~2.237,P<0.05)、吸烟(OR=1.845,95%CI 为 1.479~2.302,P<0.001)是 MCI 发生的危险因素,锻炼频率高(OR=0.845,95%CI 为 0.742~0.964,P<0.05)是MCI发生的保护因素.结论 上海市嘉定区嘉定镇社区老年人群MCI发生率较高,职业属性、有忌口、锻炼频率、吸烟是MCI发生的影响因素.
Objective To investigate the prevalence and related factors of mild cognitive impairment(MCI)in elderly people aged 60 years and above in Jiading Town of Jiading District,Shanghai.Methods This was a cross-sectional study.A total of 860 people were selected from 4 962 physical examinees(≥60 years old)from May to July 2020 by simple random sampling.Of them,48 people refused to accept the investigation or partial investigation,and 812 people accepted the full investigation.A questionnaire survey was conducted to collect basic information,demographic data,chronic diseases,and lifestyle of the participants.Accroding to the Petersen criteria,the occurrence of MCI was assessed by montreal cognitive assessment-basic(MoCA-B),activities of daily living(ADL)scale,and clinical dementia rating(CDR)scale.MCI was finally confirmed by a psychiatrist.MCI prevalence was calculated,and influencing factors were invetigated.Results Of the 812 people surveyed,791 valid questionnaires were collected,with an effective rate of 97.41%.A total of 755 people were included in the analysis,including 192 MCI people and 563 people with normal cognition.The incidence of MCI significantly increased with age(x2=19.120,P<0.01).When the education years≤12 years,the incidence of MCI was negatively related to education years,while when the education years were>12 years,the incidence of MCI was positively related to education years(x2=21.670,P<0.01).The more children they had,the higher the incidence of MCI(x2=11.460,P<0.01).The incidence of MCI in the peole who were primarily engaged in physical labor was significantly higher than that in the people with mental labor(x2=22.110,P<0.01).The incidence of MCI in the people with central obesity was significantly higher than that in the people without central obesity(x2=4.661,P=0.031).The incidence of MCI in the people with diabetes was significantly higher than that in the people without diabetes(x2=6.012,P=0.014).The incidences of MCI were significantly higher in the people who had dietary restrictions and still smoked than those in the people who were not restricted,did not smoke,or had already quit smoking(x2=7.807 or 44.555,P=0.005 or P<0.01).The incidences of MCI were significantly lower in the people who could speak foreign language and took exercise frequently than those in the people who could not speak foreign language and took exercise occasionally(x2=3.962 or 17.014,P=0.047 or 0.001).Binary logistic regression analysis was performed with statistically significant variables in the above univariate analysis(age,education years,the number of children,occupation,diabetes,central obesity,special dietary restriction,smoking,ability to speak foreign language,and exercise frequency)as independent variables and MCI as dependent variables.And the result showed physical labor(OR=2.525,95%CI:1.618-3.939,P<0.001),special dietary restriction(OR=1.529,95%CI:1.045-2.237,P<0.05)and smoking(OR=1.845,95%CI:1.479-2.302,P<0.001)were risk factors for the occurrence of MCI,while high exercise frequency was a protective factor for the occurrence of MCI(OR=0.845,95%CI:0.742-0.964,P<0.05).Conclusion There is a high prevalence of MCI in the elderly population in Jiading Town of Jiading District,Shanghai.The occupation,special dietary restriction,physical exercise and smoking are factors influencing the occurrence of MCI.

Mild cognitive impairmentDisease statusRelated factors

刘亚林、陆媛、徐圣明、周路路、薛娅雅、李凯、翟佳燚、黄武全、陆晓瑜、于德华

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201899 上海,上海市嘉定区嘉定镇街道社区卫生服务中心全科医疗科

同济大学附属杨浦医院全科医学科

上海市嘉定区南翔镇社区卫生服务中心全科医疗科

上海市浦东新区潍坊社区卫生服务中心

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轻度认知功能障碍 老年群体 影响因素

上海市卫生健康委科研项目上海市"医苑新星"青年医学人才培养资助计划(2022)

20194Y0159沪卫人事[2023]62号

2024

上海医学
上海市医学会

上海医学

CSTPCD
影响因子:0.582
ISSN:0253-9934
年,卷(期):2024.47(1)
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