Objective To investigate the association between 25-hydroxyvitamin D[25(OH)D]and the risk of incident non-alcoholic fatty liver disease(NAFLD)in East China and evaluate whether the association was modified by genetic predisposition.Methods The data were obtained from the Survey on Prevalence in East China for Metabolic Diseases and Risk Factors(SPECT-China)cohort.According to ultrasonic assessments,1 624 participants free of NAFLD at baseline were included.A weighted genetic risk score for NAFLD were calculated in 1 126 participants.Logistic regressive models were used to examine the OR and 95％Cl for the risk of NAFLD.Results After a 5-year follow-up,a total of 197 NAFLD cases were documented.After adjusting for age,sex and BMI,serum 25(OH)D levels were significantly associated with incident NAFLD[per 1-SD increment,OR=0.81,95％Cl:0.68-0.97]and there was a significant decreasing trend of NAFLD risk across 25(OH)D quartiles(P for trend 0.01;quartile 4 vs.1,OR=0.61,95％Cl:0.39-0.96).However,after further adjusting for smoking status,drinking status,diabetes,hypertension,and triglycerides,the association was largely attenuated(per 1-SD increment,OR=0.87,95％Cl=0.73-1.04)and the trend significance was also attenuated in the final model(P for trend=0.09).Additionally,no significant interaction effect was observed among 25(OH)D,genetic predisposition and incident NAFLD.Conclusion Serum 25(OH)D levels are not statistically associated with incident NAFLD regardless of genetic predisposition.Studies with larger sample size and intervention nature are warranted.
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万方数据