Relationship between Kindlin-1 and Myc-induced nuclear antigen 53 with clinicopathologic features of gallbladder carcinoma
Objective To investigate the differences in Kindlin-1 and Mina53 expression between gallbladder carcinoma and the paracancerous tissues,and their relationship with the clinicopathological features.Methods Fifty-two specimens of gallbladder cancer patients who underwent surgical resection at the General Surgery Department of the Second People's Hospital of Lanzhou City between October 2016 and April 2020 were selected,and 32 specimens of paracancerous tissues were selected as the controls.Immunohistochemistry was used to detect the expression of Kindlin-1 and Mina53 in gallbladder cancer and paracancerous tissues.Comparisons were made between groups using pearson chi-square test and Fisher's exact probability method.Kaplan-Meier one-way survival analysis was used to analyze the relationship between Kindlin-1,Mina53 positivity and survival of gallbladder cancer patients.Results The positive expression rates of kindlin-1 and Mina53 in carcinoma tissues were significantly higher than those in paracancerous tissues(P＜0.001 or 0.05).The expressions of kindlin-1 and Mina53 were positively correlated with the invasion depth,differentiation degree,TNM stage and the presence of lymph node metastasis,liver metastasis,neurological invasion,and vascular invasion(all P＜0.05).Kaplan-Meier one-way survival analysis showed that kindlin-1 and Mina53 positive patients had a significantly shorter survival compared with those with negative patients(P＞0.05).Conclusion The expression levels of kindlin-1 and Mina53 are higher in gallbladder carcinoma tissues and they are correlated with tumor differentiation and lymphatic metastasis.Kindlin-1 and Mina53 are positively correlated with each other,which may serve as a reference index for clinical diagnosis and treatment of gallbladder carcinoma.
万方数据
维普
