人乳头瘤病毒检测的临床意义
Clinical significance of human papillomavirus determination
刘晓艳 1徐萍1
作者信息
- 1. 复旦大学附属妇产科医院检验科,上海,200011
- 折叠
摘要
目的 探讨多种检测手段联合对于宫颈癌及癌前病变的检测效果.方法 1 754例患者生殖道人乳头瘤病毒(HPV)DNA阳性患者中1 081例进行阴道镜检测,488例患者进行细胞学检测.结果 阴道镜检测阳性511例,阳性率为46%,细胞学检测阳性96例,阳性率为20%;HPV DNA检测阳性,细胞学阴性,阴道镜阴性244例;HPV DNA检测阳性,细胞学阳性,阴道镜阳性77例;HPV DNA检测阳性,细胞学阳性,阴道镜阴性19例;HPV DNA检测阳性,细胞学阴性,阴道镜阳性148例.扁平湿疣261例(51%),尖锐湿疣52例(10%),宫颈上皮内瘤变(CIN)Ⅰ 99例(19%),CINⅡ 155例(30%),CINⅢ 150例(29%),宫颈癌47例(9%).结论 HPV DNA检测作为有效的筛查手段必不可少,同时还需结合细胞学检测及阴道镜检测,以提高准确率.
Abstract
Objective To explore the determination effect of a variety of detection methods combined for the detection of cervical cancer and precancerous disease. Methods In 1 754 cases of human papillomavirus (HPV)DNA-positive patients, 1 081 cases were tested by colposcopy, and 488 patients were tested by cytologic examination.Results 511 patients were positive by colposcopy, and the positive rate was 46％. 96 cases were positive in cytologic examination, and the positive rate was 20％. 244 cases were HPV DNA testing positive, cytologic examination negative and colposcopy negative. 77 cases were HPV DNA testing positive, cytologic examination positive and colposcopy positive. 19 cases were HPV DNA testing positive, cytologic examination positive and colposcopy negative. 148 cases were HPV DNA testing positive, cytologic examination negative and colposcopy positive. 261 cases (51％) were flat condyloma. 52 cases ( 10％ ) were condyloma. There were 99 cervical intraepithelial neoplasia (CIN) Ⅰ ( 19％ ), 155 CIN Ⅱ (30％) and 150 CIN Ⅲ (29％). 47 cases (9％) were cervical cancer. Conclusions HPV DNA testing as an effective means of screening was essential, and cytologic examination and colposcopy are also needed to improve accuracy.
关键词
人乳头瘤病毒/DNA/阴道镜/细胞学检测/宫颈上皮内瘤变Key words
Human papillomavirus/DNA/Colposcopy/Cytologic examination/Cervical intraepithelial neoplasia引用本文复制引用
出版年
2011
NETL
NSTL
维普
万方数据